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Frailty and depressive symptoms in relation to cardiovascular disease risk in middle-aged and older adults

Author

Listed:
  • Zheng Zhang

    (Ministry of Education
    South China Normal University
    South China Normal University
    South China Normal University)

  • Huijie Xu

    (Huazhong University of Science and Technology)

  • Runjia Zhang

    (Ministry of Education
    South China Normal University
    South China Normal University
    South China Normal University)

  • Yangxinyu Yan

    (Ministry of Education
    South China Normal University
    South China Normal University
    South China Normal University)

  • Xi Ling

    (Ministry of Education
    South China Normal University
    South China Normal University
    South China Normal University)

  • Yun Meng

    (Ministry of Education
    South China Normal University
    South China Normal University
    South China Normal University)

  • Xilin Zhang

    (Ministry of Education
    South China Normal University
    South China Normal University
    South China Normal University)

  • Yuanyuan Wang

    (Ministry of Education
    South China Normal University
    South China Normal University
    South China Normal University)

Abstract

As global aging accelerates, frailty and depressive symptoms have emerged as critical contributors to cardiovascular disease (CVD) risk among older adults. However, the dynamic interplay between these factors remains underexplored. Here, we examine the associations among frailty, depressive symptoms, and incident CVD using data from five international cohorts (HRS, CHARLS, SHARE, ELSA, MHAS) involving individuals aged 50 and above. Our findings reveal that frailty significantly increases CVD risk, with depressive symptoms partially mediating this relationship. Transitions into frailty elevate CVD risk, while improvements reduce it. Cross-lagged panel network analysis identifies consistent CVD predictors, including hypertension, diabetes, and mobility issues. Subgroups with stronger associations include frail males, older individuals, working or retired people, and those with unhealthy lifestyles. These results underscore the need for integrated interventions targeting frailty and depressive symptoms to prevent CVD in aging populations.

Suggested Citation

  • Zheng Zhang & Huijie Xu & Runjia Zhang & Yangxinyu Yan & Xi Ling & Yun Meng & Xilin Zhang & Yuanyuan Wang, 2025. "Frailty and depressive symptoms in relation to cardiovascular disease risk in middle-aged and older adults," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61089-2
    DOI: 10.1038/s41467-025-61089-2
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    References listed on IDEAS

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