IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-61020-9.html
   My bibliography  Save this article

Noncanonical short-latency auditory pathway directly activates deep cortical layers

Author

Listed:
  • Michellee M. Garcia

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Amber M. Kline

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Koun Onodera

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Hiroaki Tsukano

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Pranathi R. Dandu

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Hailey C. Acosta

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Michael R. Kasten

    (University of North Carolina at Chapel Hill)

  • Paul B. Manis

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Hiroyuki K. Kato

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill
    Massachusetts Eye and Ear
    Harvard Medical School)

Abstract

Auditory processing in the cerebral cortex is considered to begin with thalamocortical inputs to layer 4 (L4) of the primary auditory cortex (A1). In this canonical model, A1 L4 inputs initiate a hierarchical cascade that propagates to higher-order cortices for slower integration of complex sounds. Here, we identify parallel ascending pathways in mice that bypass A1 and directly reach the secondary auditory cortex (A2), alongside the canonical hierarchical route. We found that layer 6 (L6) of both A1 and A2 receive short-latency (

Suggested Citation

  • Michellee M. Garcia & Amber M. Kline & Koun Onodera & Hiroaki Tsukano & Pranathi R. Dandu & Hailey C. Acosta & Michael R. Kasten & Paul B. Manis & Hiroyuki K. Kato, 2025. "Noncanonical short-latency auditory pathway directly activates deep cortical layers," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61020-9
    DOI: 10.1038/s41467-025-61020-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-61020-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-61020-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61020-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.