IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-60485-y.html
   My bibliography  Save this article

Impact of HLA evolutionary divergence and donor-recipient molecular mismatches on antibody-mediated rejection of kidney allografts

Author

Listed:
  • Zeynep Demir

    (Université Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration)

  • Marc Raynaud

    (Université Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration)

  • Gillian Divard

    (Université Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration
    Assistance Publique—Hôpitaux de Paris)

  • Kevin Louis

    (Université Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration
    Assistance Publique—Hôpitaux de Paris)

  • Agathe Truchot

    (Université Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration)

  • Matthias Niemann

    (PIRCHE AG
    Charité Universitätsmedizin Berlin)

  • Renata Ponsirenas

    (Université Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration)

  • Olivier Aubert

    (Université Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration
    Assistance Publique—Hôpitaux de Paris)

  • Arnaud Del Bello

    (University Paul Sabatier)

  • Alexandre Hertig

    (Foch Hospital)

  • Dany Anglicheau

    (Assistance Publique—Hôpitaux de Paris)

  • Bethany Dale

    (PIRCHE AG)

  • Nassim Kamar

    (University Paul Sabatier)

  • Massimo Mangiola

    (NYU Langone Health)

  • Adriana Zeevi

    (University of Pittsburgh Medical Center)

  • Carmen Lefaucheur

    (Assistance Publique—Hôpitaux de Paris)

  • Alexandre Loupy

    (Université Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration
    Assistance Publique—Hôpitaux de Paris)

Abstract

Several in-silico methods emerge to assess HLA immunogenicity and stratify immunological risk, including HLA molecular mismatches and HLA evolutionary divergence (HED). However, their added value in risk-stratifying antibody-mediated rejection (AMR) remains uncertain. We include 5159 kidney transplant recipients from four centers. Thirty-three clinical and immunological parameters are assessed, including HLA eplet mismatches, PIRCHE-II scores, and HED. Their associations with AMR are evaluated using Cox models. AMR occurrs in 1024 patients (19.9%). Immunological determinants of AMR include anti-HLA DSA (MFI:500-1400, HR:1.87; MFI > 1400, HR:3.84, p

Suggested Citation

  • Zeynep Demir & Marc Raynaud & Gillian Divard & Kevin Louis & Agathe Truchot & Matthias Niemann & Renata Ponsirenas & Olivier Aubert & Arnaud Del Bello & Alexandre Hertig & Dany Anglicheau & Bethany Da, 2025. "Impact of HLA evolutionary divergence and donor-recipient molecular mismatches on antibody-mediated rejection of kidney allografts," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60485-y
    DOI: 10.1038/s41467-025-60485-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-60485-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-60485-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Seungho Cook & Wanson Choi & Hyunjoon Lim & Yang Luo & Kunhee Kim & Xiaoming Jia & Soumya Raychaudhuri & Buhm Han, 2021. "Accurate imputation of human leukocyte antigens with CookHLA," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Maguire, Chelsea & Crivello, Pietro & Fleischhauer, Katharina & Isaacson, Dylan & Casillas, Aurora & Kramer, Cynthia S. M. & Copley, Hannah c. & Heidt, Sebastiaan & Kosmoliaptsis, Vasilis & Meneghini,, 2024. "Qualitative, rather than quantitative, differences between HLA‐DQ alleles affect HLA‐DQ immunogenicity in organ transplantation," LSE Research Online Documents on Economics 122550, London School of Economics and Political Science, LSE Library.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Pooja Middha & Rohit Thummalapalli & Michael J. Betti & Lydia Yao & Zoe Quandt & Karmugi Balaratnam & Cosmin A. Bejan & Eduardo Cardenas & Christina J. Falcon & David M. Faleck & Matthew A. Gubens & S, 2024. "Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60485-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.