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Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes

Author

Listed:
  • Alex Soupir

    (Moffitt Cancer Center)

  • Oscar E. Ospina

    (Moffitt Cancer Center)

  • Oliver Hampton

    (Aster Insights)

  • Michelle Churchman

    (Aster Insights)

  • Michael Radmacher

    (Aster Insights)

  • Dale Hedges

    (Aster Insights)

  • David McKean

    (Aster Insights)

  • Phaedra Agius

    (Aster Insights)

  • Saman Zeeshan

    (University of Missouri)

  • Nathan D. Seligson

    (University of Florida)

  • Raphael Pollock

    (The Ohio State University Comprehensive Cancer Center, College of Medicine, The Ohio State University Wexner Medical Center)

  • David Liebner

    (The Ohio State University Wexner Medical Center)

  • James L. Chen

    (The Ohio State University Wexner Medical Center)

  • Gabriel Tinoco

    (The Ohio State University Wexner Medical Center)

  • Bodour Salhia

    (Los Angeles)

  • Martin McCarter

    (University of Colorado School of Medicine)

  • Breelyn A. Wilky

    (University of Colorado School of Medicine)

  • Benjamin J. Miller

    (University of Iowa)

  • Michael J. Cavnar

    (University of Kentucky)

  • John S. Groundland

    (Huntsman Cancer Institute)

  • Bryan P. Schneider

    (Indiana University Simon Comprehensive Cancer Center)

  • Gregory Riedlinger

    (Rutgers Cancer Institute of New Jersey)

  • Stephen B. Edge

    (Roswell Park Comprehensive Cancer Center)

  • Christopher A. Moskaluk

    (University of Virginia)

  • Kenneth Cardona

    (Emory University)

  • Abdul Rafeh Naqash

    (University of Oklahoma Health Sciences)

  • Ricardo J. Gonzalez

    (Moffitt Cancer Center)

  • John E. Mullinax

    (Moffitt Cancer Center)

  • David M. Joyce

    (Moffitt Cancer Center)

  • Odion Binitie

    (Moffitt Cancer Center)

  • G. Douglas Letson

    (Moffitt Cancer Center)

  • Arash O. Naghavi

    (Moffitt Cancer Center)

  • Mihaela Druta

    (Moffitt Cancer Center)

  • Damon R. Reed

    (Moffitt Cancer Center)

  • Erin M. Siegel

    (Moffitt Cancer Center)

  • Jamie K. Teer

    (Moffitt Cancer Center)

  • Brooke L. Fridley

    (Moffitt Cancer Center
    Children’s Mercy)

  • Andrew S. Brohl

    (Moffitt Cancer Center)

Abstract

Given their rarity and diversity, a fundamental understanding of the genomic underpinnings for many sarcoma subtypes is still lacking. To better define the molecular landscape of this group of diseases, we perform matched whole exome sequencing and RNA sequencing on a cohort of 1340 sarcoma tumor specimens. We identify recurrent somatic mutations and observe an increased mutational burden in metastatic vs. primary samples (p

Suggested Citation

  • Alex Soupir & Oscar E. Ospina & Oliver Hampton & Michelle Churchman & Michael Radmacher & Dale Hedges & David McKean & Phaedra Agius & Saman Zeeshan & Nathan D. Seligson & Raphael Pollock & David Lieb, 2025. "Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58678-6
    DOI: 10.1038/s41467-025-58678-6
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    References listed on IDEAS

    as
    1. Mrinal M. Gounder & Narasimhan P. Agaram & Sally E. Trabucco & Victoria Robinson & Richard A. Ferraro & Sherri Z. Millis & Anita Krishnan & Jessica Lee & Steven Attia & Wassim Abida & Alexander Drilon, 2022. "Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Benjamin A. Nacev & Francisco Sanchez-Vega & Shaleigh A. Smith & Cristina R. Antonescu & Evan Rosenbaum & Hongyu Shi & Cerise Tang & Nicholas D. Socci & Satshil Rana & Rodrigo Gularte-Mérida & Ahmet Z, 2022. "Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Florent Petitprez & Aurélien Reyniès & Emily Z. Keung & Tom Wei-Wu Chen & Cheng-Ming Sun & Julien Calderaro & Yung-Ming Jeng & Li-Ping Hsiao & Laetitia Lacroix & Antoine Bougoüin & Marco Moreira & Gui, 2020. "B cells are associated with survival and immunotherapy response in sarcoma," Nature, Nature, vol. 577(7791), pages 556-560, January.
    Full references (including those not matched with items on IDEAS)

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