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Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore

Author

Listed:
  • Sabrina Mai

    (University of Rochester
    University of Rochester School of Medicine
    University of Rochester School of Medicine
    University of Rochester)

  • Allison J. Murphy

    (University of Rochester
    University of Rochester School of Medicine
    University of Rochester School of Medicine
    University of Rochester)

  • J. Michael Hasse

    (New York University)

  • Farran Briggs

    (University of Rochester
    University of Rochester School of Medicine
    University of Rochester School of Medicine
    University of Rochester)

Abstract

Sensory circuits are organized in parallel, e.g. parallel streams relay feedforward visual information from retina to cortex. Corticogeniculate (CG) feedback is also organized in parallel; however, stream-specific influences of CG feedback remained unresolved. We utilized optogenetics to manipulate CG feedback in monkeys while recording geniculate responses to a comprehensive set of visual stimuli designed to probe stream-specific responses. Here we show that CG feedback improved the spatial resolution of magnocellular, but not parvocellular neurons. Optogenetically enhancing CG feedback increased extraclassical surround suppression, shrunk classical receptive fields, and increased preferred spatial frequencies among magnocellular neurons. Optogenetically suppressing CG feedback reduced surround suppression. Enhancing CG feedback in female ferrets revealed similar stream-specific effects in geniculate Y, but not X neurons. Furthermore, optogenetically enhancing CG feedback improved temporal response precision across neuronal types. These results support dual functional roles for CG feedback in enhancing spatial resolution in a stream-specific manner and improving temporal precision broadly.

Suggested Citation

  • Sabrina Mai & Allison J. Murphy & J. Michael Hasse & Farran Briggs, 2025. "Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58667-9
    DOI: 10.1038/s41467-025-58667-9
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    References listed on IDEAS

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    1. Lauri Nurminen & Sam Merlin & Maryam Bijanzadeh & Frederick Federer & Alessandra Angelucci, 2018. "Top-down feedback controls spatial summation and response amplitude in primate visual cortex," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
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