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Programmable production of bioactive extracellular vesicles in vivo to treat myocardial infarction

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  • Siyuan Fu

    (Nanjing University of Posts and Telecommunications)

  • Zhiyu Wang

    (Nanjing University of Posts and Telecommunications)

  • Peihong Huang

    (Nanjing University of Posts and Telecommunications)

  • Guanjun Li

    (Nanjing University of Posts and Telecommunications)

  • Jian Niu

    (Nanjing University of Posts and Telecommunications)

  • Zhiyang Li

    (Nanjing University)

  • Guangyue Zu

    (Chinese Academy of Sciences)

  • Pengcheng Zhou

    (Affiliated Hospital of Nantong University)

  • Lianhui Wang

    (Nanjing University of Posts and Telecommunications)

  • David Tai Leong

    (National University of Singapore)

  • Xianguang Ding

    (Nanjing University of Posts and Telecommunications)

Abstract

Current myocardial infarction (MI) treatment strategies remain challenged in suboptimal pharmacokinetics and potential adverse effects. Here we present a bioelectronic interface capable of producing on-demand abundant bioactive extracellular vesicles (EVs) near the MI area for in-situ localized treatment. The technology, termed electroactive patch for wirelessly and controllable EV generation (ePOWER), leverages wireless bioelectronic patch to stimulate embedded electrosensitive macrophages, actively modulating the biosynthesis of EVs and enabling EV production with high programmability to be delivered directly to the MI area. ~2400% more bioactive EVs were produced per cell under our ePOWER system. When surgically implanted, we demonstrate the therapeutic potential of in-situ EV production system to alleviate MI symptoms and improve cardiac function. This programmable ePOWER technology enables in-situ production of therapeutically rich EVs, thus reducing the need for exogenous cell expansion platforms and dedicated delivery, holding promise as a therapeutic all-in-one platform to treat various diseases.

Suggested Citation

  • Siyuan Fu & Zhiyu Wang & Peihong Huang & Guanjun Li & Jian Niu & Zhiyang Li & Guangyue Zu & Pengcheng Zhou & Lianhui Wang & David Tai Leong & Xianguang Ding, 2025. "Programmable production of bioactive extracellular vesicles in vivo to treat myocardial infarction," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58260-0
    DOI: 10.1038/s41467-025-58260-0
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    1. Shuangshuang Wan & Kepeng Wang & Peihong Huang & Xian Guo & Wurui Liu & Yaocheng Li & Jingjing Zhang & Zhiyang Li & Jiacheng Song & Wenjing Yang & Xianzheng Zhang & Xianguang Ding & David Tai Leong & , 2024. "Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Yuhuan Li & Nengyi Ni & Myeongsang Lee & Wei Wei & Nicholas Andrikopoulos & Aleksandr Kakinen & Thomas P. Davis & Yang Song & Feng Ding & David Tai Leong & Pu Chun Ke, 2024. "Endothelial leakiness elicited by amyloid protein aggregation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Tongbiao Zhao & Zhen-Ning Zhang & Zhili Rong & Yang Xu, 2011. "Immunogenicity of induced pluripotent stem cells," Nature, Nature, vol. 474(7350), pages 212-215, June.
    4. Dashuai Zhu & Zhenhua Li & Ke Huang & Thomas G. Caranasos & Joseph S. Rossi & Ke Cheng, 2021. "Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    5. Serena Zacchigna & Valentina Martinelli & Silvia Moimas & Andrea Colliva & Marco Anzini & Andrea Nordio & Alessia Costa & Michael Rehman & Simone Vodret & Cristina Pierro & Giulia Colussi & Lorena Zen, 2018. "Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
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