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Can a single brain cell be surprised?

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  • Karl J. Friston

    (University College London)

Abstract

A recent study by Buonomano et al. reports two important contributions; namely, empirical evidence for prediction error-like responses in single cells, using ex vivo preparations and optogenetics. Second, it foregrounds the role of asymmetric coupling in generating itinerant dynamics required for temporal prediction in neuronal circuits.

Suggested Citation

  • Karl J. Friston, 2025. "Can a single brain cell be surprised?," Nature Communications, Nature, vol. 16(1), pages 1-2, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57975-4
    DOI: 10.1038/s41467-025-57975-4
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    References listed on IDEAS

    as
    1. Sevada Hovsepyan & Itsaso Olasagasti & Anne-Lise Giraud, 2020. "Combining predictive coding and neural oscillations enables online syllable recognition in natural speech," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    2. Benjamin Liu & Dean V. Buonomano, 2025. "Ex vivo cortical circuits learn to predict and spontaneously replay temporal patterns," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
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