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Optically tunable catalytic cancer therapy using enzyme-like chiral plasmonic nanoparticles

Author

Listed:
  • Haeun Kang

    (Ewha Womans University)

  • Subin Yu

    (Ewha Womans University
    Brigham and Women’s Hospital)

  • Ryeong Myeong Kim

    (Seoul National University)

  • Youngbi Kim

    (Pohang University of Science and Technology)

  • Sang Chul Shin

    (Korea Institute of Science and Technology)

  • Dohyub Jang

    (Korea University)

  • Jeong Hyun Han

    (Seoul National University)

  • Sugyeong Hong

    (Korea Basic Science Institute)

  • Eunice EunKyeong Kim

    (Korea Institute of Science and Technology)

  • Sun Hee Kim

    (Korea Basic Science Institute
    Chung-Ang University)

  • Dong June Ahn

    (Korea University
    Korea University)

  • Jeong Woo Han

    (Seoul National University)

  • Sehoon Kim

    (Korea University
    Korea Institute of Science and Technology)

  • Ki Tae Nam

    (Seoul National University)

  • Luke P. Lee

    (Brigham and Women’s Hospital
    Berkeley
    Berkeley
    Sungkyunkwan University)

  • Dong Ha Kim

    (Ewha Womans University
    Ewha Womans University
    Ewha Womans University
    Ewha Womans University)

Abstract

Cascade enzymatic reactions in living organisms are fundamental reaction mechanisms in coordinating various complex biochemical processes such as metabolism, signal transduction, and gene regulation. Many studies have attempted to mimic cascade reactions using nanoparticles with enzyme-like activity; however, precisely tuning each reaction within complex networks to enhance the catalytic activity remains challenging. Here, we present enzyme-like chiral plasmonic nanoparticles for optically tunable catalytic cancer therapy. We create chiral plasmonic nanoparticles with glucose oxidase (GOD) and peroxidase (POD) activities, followed by introducing circularly polarized light (CPL). By sequentially activating GOD and POD reactions with right-handed CPL (RC) followed by left-handed CPL (LC), we achieve 1.25- and 1.9-fold enhanced catalytic performance (overall 1.3 times enhancement) compared to non-controlled cascade reactions by creating an optimal acidic environment for the subsequent reaction. Moreover, the D-Au nanoparticle shows a 2-fold higher binding selectivity to D-glucose substrates, attributed to chirality matching. In both cell studies and male mouse models, sequentially irradiated groups (RC followed by LC) exhibit the highest radical generation and the most efficient treatment outcomes compared to the other systems under different irradiation conditions. We believe that our system holds strong potential for medical applications, suggesting a promising platform for catalytic therapy.

Suggested Citation

  • Haeun Kang & Subin Yu & Ryeong Myeong Kim & Youngbi Kim & Sang Chul Shin & Dohyub Jang & Jeong Hyun Han & Sugyeong Hong & Eunice EunKyeong Kim & Sun Hee Kim & Dong June Ahn & Jeong Woo Han & Sehoon Ki, 2025. "Optically tunable catalytic cancer therapy using enzyme-like chiral plasmonic nanoparticles," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57716-7
    DOI: 10.1038/s41467-025-57716-7
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    References listed on IDEAS

    as
    1. Christoph Hold & Sonja Billerbeck & Sven Panke, 2016. "Forward design of a complex enzyme cascade reaction," Nature Communications, Nature, vol. 7(1), pages 1-8, December.
    2. Hye-Eun Lee & Hyo-Yong Ahn & Jungho Mun & Yoon Young Lee & Minkyung Kim & Nam Heon Cho & Kiseok Chang & Wook Sung Kim & Junsuk Rho & Ki Tae Nam, 2018. "Amino-acid- and peptide-directed synthesis of chiral plasmonic gold nanoparticles," Nature, Nature, vol. 556(7701), pages 360-365, April.
    3. Danny Porath & Alexey Bezryadin & Simon de Vries & Cees Dekker, 2000. "Direct measurement of electrical transport through DNA molecules," Nature, Nature, vol. 403(6770), pages 635-638, February.
    4. Ge Fang & Weifeng Li & Xiaomei Shen & Jose Manuel Perez-Aguilar & Yu Chong & Xingfa Gao & Zhifang Chai & Chunying Chen & Cuicui Ge & Ruhong Zhou, 2018. "Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    5. Ryeong Myeong Kim & Ji-Hyeok Huh & SeokJae Yoo & Tae Gyun Kim & Changwon Kim & Hyeohn Kim & Jeong Hyun Han & Nam Heon Cho & Yae-Chan Lim & Sang Won Im & EunJi Im & Jae Ryeol Jeong & Min Hyung Lee & Ta, 2022. "Enantioselective sensing by collective circular dichroism," Nature, Nature, vol. 612(7940), pages 470-476, December.
    6. Jinxing Chen & Qian Ma & Minghua Li & Daiyong Chao & Liang Huang & Weiwei Wu & Youxing Fang & Shaojun Dong, 2021. "Glucose-oxidase like catalytic mechanism of noble metal nanozymes," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
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