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Epigenomic and proteomic analyses provide insights into early-life immune regulation and asthma development in infants

Author

Listed:
  • Yijun Li

    (Harvard T.H. Chan School of Public Health)

  • Zhaozhong Zhu

    (Harvard Medical School)

  • Carlos A. Camargo

    (Harvard Medical School)

  • Janice A. Espinola

    (Harvard Medical School)

  • Kohei Hasegawa

    (Harvard Medical School)

  • Liming Liang

    (Harvard T.H. Chan School of Public Health
    Harvard T.H. Chan School of Public Health)

Abstract

Infants with severe bronchiolitis (i.e., bronchiolitis requiring hospitalization) face increased risks of respiratory diseases in childhood. We conduct epigenome-wide association studies in a multi-ethnic cohort of these infants. We identify 61 differentially methylated regions in infant blood (

Suggested Citation

  • Yijun Li & Zhaozhong Zhu & Carlos A. Camargo & Janice A. Espinola & Kohei Hasegawa & Liming Liang, 2025. "Epigenomic and proteomic analyses provide insights into early-life immune regulation and asthma development in infants," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57288-6
    DOI: 10.1038/s41467-025-57288-6
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