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A critical role of action-related functional networks in Gilles de la Tourette syndrome

Author

Listed:
  • Juan Carlos Baldermann

    (Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
    Faculty of Medicine and University Hospital Cologne, University of Cologne)

  • Jan Niklas Petry-Schmelzer

    (Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg)

  • Thomas Schüller

    (Faculty of Medicine and University Hospital Cologne, University of Cologne)

  • Lin Mahfoud

    (Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg)

  • Gregor A. Brandt

    (Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg)

  • Till A. Dembek

    (Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg)

  • Christina Linden

    (Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg)

  • Joachim K. Krauss

    (Hannover Medical School)

  • Natalia Szejko

    (University of Calgary
    Socialpsychiatry and Psychotherapy, Hannover Medical School
    Medical University of Warsaw)

  • Kirsten R. Müller-Vahl

    (Socialpsychiatry and Psychotherapy, Hannover Medical School)

  • Christos Ganos

    (Toronto Western Hospital)

  • Bassam Al-Fatly

    (Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Petra Heiden

    (Faculty of Medicine and University Hospital Cologne, University of Cologne)

  • Domenico Servello

    (Milan)

  • Tommaso Galbiati

    (Milan)

  • Kara A. Johnson

    (University of Florida)

  • Christopher R. Butson

    (University of Florida
    University of Florida, Gainesville, FL, USA; J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida)

  • Michael S. Okun

    (University of Florida)

  • Pablo Andrade

    (Faculty of Medicine and University Hospital Cologne, University of Cologne)

  • Katharina Domschke

    (Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
    Partner Site Berlin)

  • Gereon R. Fink

    (Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
    Research Center Jülich)

  • Michael D. Fox

    (Harvard Medical School)

  • Andreas Horn

    (Harvard Medical School
    Charité – Universitätsmedizin Berlin
    Charité – Universitätsmedizin Berlin
    Massachusetts General Hospital, Harvard Medical School)

  • Jens Kuhn

    (Alexianer Köln GmbH
    Faculty of Medicine and University Hospital Cologne, University of Cologne)

  • Veerle Visser-Vandewalle

    (Faculty of Medicine and University Hospital Cologne, University of Cologne)

  • Michael T. Barbe

    (Faculty of Medicine and University Hospital Cologne, University of Cologne)

Abstract

Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants. We find that greater tic reduction is linked to higher connectivity of DBS sites (N = 37) with action-related functional resting-state networks, i.e., the cingulo-opercular (r = 0.62; p

Suggested Citation

  • Juan Carlos Baldermann & Jan Niklas Petry-Schmelzer & Thomas Schüller & Lin Mahfoud & Gregor A. Brandt & Till A. Dembek & Christina Linden & Joachim K. Krauss & Natalia Szejko & Kirsten R. Müller-Vahl, 2024. "A critical role of action-related functional networks in Gilles de la Tourette syndrome," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-55242-6
    DOI: 10.1038/s41467-024-55242-6
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    References listed on IDEAS

    as
    1. Shan H. Siddiqi & Frederic L. W. V. J. Schaper & Andreas Horn & Joey Hsu & Jaya L. Padmanabhan & Amy Brodtmann & Robin F. H. Cash & Maurizio Corbetta & Ki Sueng Choi & Darin D. Dougherty & Natalia Ego, 2021. "Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease," Nature Human Behaviour, Nature, vol. 5(12), pages 1707-1716, December.
    2. Evan M. Gordon & Roselyne J. Chauvin & Andrew N. Van & Aishwarya Rajesh & Ashley Nielsen & Dillan J. Newbold & Charles J. Lynch & Nicole A. Seider & Samuel R. Krimmel & Kristen M. Scheidter & Julia Mo, 2023. "A somato-cognitive action network alternates with effector regions in motor cortex," Nature, Nature, vol. 617(7960), pages 351-359, May.
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    Cited by:

    1. Samuel R. Krimmel & Timothy O. Laumann & Roselyne J. Chauvin & Tamara Hershey & Jarod L. Roland & Joshua S. Shimony & Jon T. Willie & Scott A. Norris & Scott Marek & Andrew N. Van & Anxu Wang & Julia , 2025. "The human brainstem’s red nucleus was upgraded to support goal-directed action," Nature Communications, Nature, vol. 16(1), pages 1-14, December.

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