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Cellular reprogramming as a tool to model human aging in a dish

Author

Listed:
  • Patricia R. Pitrez

    (University of Coimbra
    University of Coimbra)

  • Luis M. Monteiro

    (University of Coimbra
    University of Coimbra
    University of Coimbra, Casa Costa Alemão)

  • Oliver Borgogno

    (University of California San Diego
    The Salk Institute for Biological Studies)

  • Xavier Nissan

    (CECS, I-STEM, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic diseases)

  • Jerome Mertens

    (University of California San Diego
    The Salk Institute for Biological Studies)

  • Lino Ferreira

    (University of Coimbra
    University of Coimbra)

Abstract

The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.

Suggested Citation

  • Patricia R. Pitrez & Luis M. Monteiro & Oliver Borgogno & Xavier Nissan & Jerome Mertens & Lino Ferreira, 2024. "Cellular reprogramming as a tool to model human aging in a dish," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46004-5
    DOI: 10.1038/s41467-024-46004-5
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