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Regulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity

Author

Listed:
  • Hyung Chul Lee

    (University College London
    Chonnam National University)

  • Nidia M. M. Oliveira

    (University College London
    Murdoch University)

  • Cato Hastings

    (University College London)

  • Peter Baillie-Benson

    (The Francis Crick Institute)

  • Adam A. Moverley

    (University College London
    University of Pennsylvania)

  • Hui-Chun Lu

    (University College London
    Centre for Craniofacial & Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London)

  • Yi Zheng

    (University of Michigan
    Syracuse University
    Syracuse University)

  • Elise L. Wilby

    (University of Cambridge)

  • Timothy T. Weil

    (University of Cambridge)

  • Karen M. Page

    (University College London)

  • Jianping Fu

    (University of Michigan)

  • Naomi Moris

    (The Francis Crick Institute)

  • Claudio D. Stern

    (University College London)

Abstract

Many amniote vertebrate species including humans can form identical twins from a single embryo, but this only occurs rarely. It has been suggested that the primitive-streak-forming embryonic region emits signals that inhibit streak formation elsewhere but the signals involved, how they are transmitted and how they act has not been elucidated. Here we show that short tracks of calcium firing activity propagate through extraembryonic tissue via gap junctions and prevent ectopic primitive streak formation in chick embryos. Cross-regulation of calcium activity and an inhibitor of primitive streak formation (Bone Morphogenetic Protein, BMP) via NF-κB and NFAT establishes a long-range BMP gradient spanning the embryo. This mechanism explains how embryos of widely different sizes can maintain positional information that determines embryo polarity. We provide evidence for similar mechanisms in two different human embryo models and in Drosophila, suggesting an ancient evolutionary origin.

Suggested Citation

  • Hyung Chul Lee & Nidia M. M. Oliveira & Cato Hastings & Peter Baillie-Benson & Adam A. Moverley & Hui-Chun Lu & Yi Zheng & Elise L. Wilby & Timothy T. Weil & Karen M. Page & Jianping Fu & Naomi Moris , 2024. "Regulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45772-4
    DOI: 10.1038/s41467-024-45772-4
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    References listed on IDEAS

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