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PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development

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Listed:
  • Jong Geol Lee

    (Asan Medical Center
    Korea Mouse Phenotyping Center (KMPC)
    Korea Institute of Toxicology (KIT))

  • Jung-Min Yon

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Globinna Kim

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Seul-Gi Lee

    (Konkuk University)

  • C-Yoon Kim

    (Konkuk University)

  • Seung-A Cheong

    (Asan Medical Center)

  • Hyun-Yi Kim

    (NGeneS Inc)

  • Jiyoung Yu

    (Asan Medical Center)

  • Kyunggon Kim

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Young Hoon Sung

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Hyun Ju Yoo

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Dong-Cheol Woo

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Jin Kyung Rho

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Chang Hoon Ha

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Chan-Gi Pack

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Seak Hee Oh

    (University of Ulsan College of Medicine)

  • Joon Seo Lim

    (Asan Medical Center)

  • Yu Mi Han

    (Sungkyunkwan University School of Medicine)

  • Eui-Ju Hong

    (Chungnam National University)

  • Je Kyung Seong

    (Korea Mouse Phenotyping Center (KMPC)
    Seoul National University)

  • Han-Woong Lee

    (Yonsei University)

  • Sang-Wook Lee

    (Korea Mouse Phenotyping Center (KMPC)
    University of Ulsan College of Medicine)

  • Ki-Up Lee

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Chong Jai Kim

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • Sang-Yoon Nam

    (Chungbuk National University)

  • You Sook Cho

    (Asan Medical Center
    University of Ulsan College of Medicine)

  • In-Jeoung Baek

    (Asan Medical Center
    Korea Mouse Phenotyping Center (KMPC)
    University of Ulsan College of Medicine)

Abstract

Proper placental development in early pregnancy ensures a positive outcome later on. The developmental relationship between the placenta and embryonic organs, such as the heart, is crucial for a normal pregnancy. However, the mechanism through which the placenta influences the development of embryonic organs remains unclear. Trophoblasts fuse to form multinucleated syncytiotrophoblasts (SynT), which primarily make up the placental materno-fetal interface. We discovered that endogenous progesterone immunomodulatory binding factor 1 (PIBF1) is vital for trophoblast differentiation and fusion into SynT in humans and mice. PIBF1 facilitates communication between SynT and adjacent vascular cells, promoting vascular network development in the primary placenta. This process affected the early development of the embryonic cardiovascular system in mice. Moreover, in vitro experiments showed that PIBF1 promotes the development of cardiovascular characteristics in heart organoids. Our findings show how SynTs organize the barrier and imply their possible roles in supporting embryogenesis, including cardiovascular development. SynT-derived factors and SynT within the placenta may play critical roles in ensuring proper organogenesis of other organs in the embryo.

Suggested Citation

  • Jong Geol Lee & Jung-Min Yon & Globinna Kim & Seul-Gi Lee & C-Yoon Kim & Seung-A Cheong & Hyun-Yi Kim & Jiyoung Yu & Kyunggon Kim & Young Hoon Sung & Hyun Ju Yoo & Dong-Cheol Woo & Jin Kyung Rho & Cha, 2024. "PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45647-8
    DOI: 10.1038/s41467-024-45647-8
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    References listed on IDEAS

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