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Skin muscle is the initial site of viral replication for arboviral bunyavirus infection

Author

Listed:
  • Christine A. Schneider

    (National Institutes of Health)

  • Jacqueline M. Leung

    (National Institutes of Health)

  • Paola Carolina Valenzuela-Leon

    (National Institutes of Health)

  • Natalya A. Golviznina

    (University of Minnesota)

  • Erik A. Toso

    (University of Minnesota)

  • Darko Bosnakovski

    (University of Minnesota)

  • Michael Kyba

    (University of Minnesota)

  • Eric Calvo

    (National Institutes of Health)

  • Karin E. Peterson

    (National Institutes of Health)

Abstract

The first step in disease pathogenesis for arboviruses is the establishment of infection following vector transmission. For La Crosse virus (LACV), the leading cause of pediatric arboviral encephalitis in North America, and other orthobunyaviruses, the initial course of infection in the skin is not well understood. Using an intradermal (ID) model of LACV infection in mice, we find that the virus infects and replicates nearly exclusively within skin-associated muscle cells of the panniculus carnosus (PC) and not in epidermal or dermal cells like most other arbovirus families. LACV is widely myotropic, infecting distal muscle cells of the peritoneum and heart, with limited infection of draining lymph nodes. Surprisingly, muscle cells are resistant to virus-induced cell death, with long term low levels of virus release progressing through the Golgi apparatus. Thus, skin muscle may be a key cell type for the initial infection and spread of arboviral orthobunyaviruses.

Suggested Citation

  • Christine A. Schneider & Jacqueline M. Leung & Paola Carolina Valenzuela-Leon & Natalya A. Golviznina & Erik A. Toso & Darko Bosnakovski & Michael Kyba & Eric Calvo & Karin E. Peterson, 2024. "Skin muscle is the initial site of viral replication for arboviral bunyavirus infection," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45304-0
    DOI: 10.1038/s41467-024-45304-0
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    References listed on IDEAS

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    1. Alissa R Young & Marissa C Locke & Lindsey E Cook & Bradley E Hiller & Rong Zhang & Matthew L Hedberg & Kristen J Monte & Deborah J Veis & Michael S Diamond & Deborah J Lenschow, 2019. "Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA," PLOS Pathogens, Public Library of Science, vol. 15(8), pages 1-30, August.
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