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Dynamic neural representations of memory and space during human ambulatory navigation

Author

Listed:
  • Sabrina L. L. Maoz

    (University of California, Los Angeles
    University of California, Los Angeles
    University of California, Los Angeles)

  • Matthias Stangl

    (University of California, Los Angeles)

  • Uros Topalovic

    (University of California, Los Angeles)

  • Daniel Batista

    (University of California, Los Angeles)

  • Sonja Hiller

    (University of California, Los Angeles)

  • Zahra M. Aghajan

    (University of California, Los Angeles)

  • Barbara Knowlton

    (University of California, Los Angeles)

  • John Stern

    (University of California, Los Angeles)

  • Jean-Philippe Langevin

    (Neurosurgery Service, Department of Veterans Affairs Greater Los Angeles Healthcare System
    University of California, Los Angeles)

  • Itzhak Fried

    (University of California, Los Angeles
    University of California, Los Angeles
    Tel-Aviv University)

  • Dawn Eliashiv

    (University of California, Los Angeles)

  • Nanthia Suthana

    (University of California, Los Angeles
    University of California, Los Angeles
    University of California, Los Angeles
    University of California, Los Angeles)

Abstract

Our ability to recall memories of personal experiences is an essential part of daily life. These episodic memories often involve movement through space and thus require continuous encoding of one’s position relative to the surrounding environment. The medial temporal lobe (MTL) is thought to be critically involved, based on studies in freely moving rodents and stationary humans. However, it remains unclear if and how the MTL represents both space and memory especially during physical navigation, given challenges associated with deep brain recordings in humans during movement. We recorded intracranial electroencephalographic (iEEG) activity while participants completed an ambulatory spatial memory task within an immersive virtual reality environment. MTL theta activity was modulated by successful memory retrieval or spatial positions within the environment, depending on dynamically changing behavioral goals. Altogether, these results demonstrate how human MTL oscillations can represent both memory and space in a temporally flexible manner during freely moving navigation.

Suggested Citation

  • Sabrina L. L. Maoz & Matthias Stangl & Uros Topalovic & Daniel Batista & Sonja Hiller & Zahra M. Aghajan & Barbara Knowlton & John Stern & Jean-Philippe Langevin & Itzhak Fried & Dawn Eliashiv & Nanth, 2023. "Dynamic neural representations of memory and space during human ambulatory navigation," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42231-4
    DOI: 10.1038/s41467-023-42231-4
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    References listed on IDEAS

    as
    1. Matthias Stangl & Uros Topalovic & Cory S. Inman & Sonja Hiller & Diane Villaroman & Zahra M. Aghajan & Leonardo Christov-Moore & Nicholas R. Hasulak & Vikram R. Rao & Casey H. Halpern & Dawn Eliashiv, 2021. "Boundary-anchored neural mechanisms of location-encoding for self and others," Nature, Nature, vol. 589(7842), pages 420-425, January.
    2. Jonathan Miller & Andrew J. Watrous & Melina Tsitsiklis & Sang Ah Lee & Sameer A. Sheth & Catherine A. Schevon & Elliot H. Smith & Michael R. Sperling & Ashwini Sharan & Ali Akbar Asadi-Pooya & Gregor, 2018. "Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    3. Torkel Hafting & Marianne Fyhn & Sturla Molden & May-Britt Moser & Edvard I. Moser, 2005. "Microstructure of a spatial map in the entorhinal cortex," Nature, Nature, vol. 436(7052), pages 801-806, August.
    4. Véronique D. Bohbot & Milagros S. Copara & Jean Gotman & Arne D. Ekstrom, 2017. "Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation," Nature Communications, Nature, vol. 8(1), pages 1-7, April.
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