IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-41542-w.html
   My bibliography  Save this article

The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance

Author

Listed:
  • Sean Cavany

    (University of Oxford)

  • Stella Nanyonga

    (University of Oxford
    University of Oxford
    University of Oxford
    Mahidol University)

  • Cathrin Hauk

    (University of Oxford
    University of Oxford
    University of Oxford
    Mahidol University)

  • Cherry Lim

    (University of Oxford
    Mahidol University)

  • Joel Tarning

    (University of Oxford
    University of Oxford
    Mahidol University)

  • Benn Sartorius

    (University of Oxford
    The University of Queensland)

  • Christiane Dolecek

    (University of Oxford
    Mahidol University)

  • Céline Caillet

    (University of Oxford
    University of Oxford
    University of Oxford
    Mahidol University)

  • Paul N. Newton

    (University of Oxford
    University of Oxford
    University of Oxford
    Mahidol University)

  • Ben S. Cooper

    (University of Oxford
    Mahidol University)

Abstract

Approximately 10% of antimicrobials used by humans in low- and middle-income countries are estimated to be substandard or falsified. In addition to their negative impact on morbidity and mortality, they may also be important drivers of antimicrobial resistance. Despite such concerns, our understanding of this relationship remains rudimentary. Substandard and falsified medicines have the potential to either increase or decrease levels of resistance, and here we discuss a range of mechanisms that could drive these changes. Understanding these effects and their relative importance will require an improved understanding of how different drug exposures affect the emergence and spread of resistance and of how the percentage of active pharmaceutical ingredients in substandard and falsified medicines is temporally and spatially distributed.

Suggested Citation

  • Sean Cavany & Stella Nanyonga & Cathrin Hauk & Cherry Lim & Joel Tarning & Benn Sartorius & Christiane Dolecek & Céline Caillet & Paul N. Newton & Ben S. Cooper, 2023. "The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41542-w
    DOI: 10.1038/s41467-023-41542-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-41542-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-41542-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Viktória Lázár & Olga Snitser & Daniel Barkan & Roy Kishony, 2022. "Antibiotic combinations reduce Staphylococcus aureus clearance," Nature, Nature, vol. 610(7932), pages 540-546, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chih-Wei Chen & Nadja Leimer & Egor A. Syroegin & Clémence Dunand & Zackery P. Bulman & Kim Lewis & Yury S. Polikanov & Maxim S. Svetlov, 2023. "Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41542-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.