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mRNA-1273 bivalent (original and Omicron) COVID-19 vaccine effectiveness against COVID-19 outcomes in the United States

Author

Listed:
  • Hung Fu Tseng

    (Kaiser Permanente Southern California
    Kaiser Permanente Bernard J. Tyson School of Medicine)

  • Bradley K. Ackerson

    (Kaiser Permanente Southern California)

  • Lina S. Sy

    (Kaiser Permanente Southern California)

  • Julia E. Tubert

    (Kaiser Permanente Southern California)

  • Yi Luo

    (Kaiser Permanente Southern California)

  • Sijia Qiu

    (Kaiser Permanente Southern California)

  • Gina S. Lee

    (Kaiser Permanente Southern California)

  • Katia J. Bruxvoort

    (Kaiser Permanente Southern California
    University of Alabama at Birmingham)

  • Jennifer H. Ku

    (Kaiser Permanente Southern California)

  • Ana Florea

    (Kaiser Permanente Southern California)

  • Harpreet S. Takhar

    (Kaiser Permanente Southern California)

  • Radha Bathala

    (Kaiser Permanente Southern California)

  • Cindy Ke Zhou

    (Moderna Inc.)

  • Daina B. Esposito

    (Moderna Inc.)

  • Morgan A. Marks

    (Moderna Inc.)

  • Evan J. Anderson

    (Moderna Inc.)

  • Carla A. Talarico

    (Moderna Inc.
    AstraZeneca)

  • Lei Qian

    (Kaiser Permanente Southern California)

Abstract

The bivalent (original and Omicron BA.4/BA.5) mRNA-1273 COVID-19 vaccine was authorized to offer broader protection against COVID-19. We conducted a matched cohort study to evaluate the effectiveness of the bivalent vaccine in preventing hospitalization for COVID-19 (primary outcome) and medically attended SARS-CoV-2 infection and hospital death (secondary outcomes). Compared to individuals who did not receive bivalent mRNA vaccination but received ≥2 doses of any monovalent mRNA vaccine, the relative vaccine effectiveness (rVE) against hospitalization for COVID-19 was 70.3% (95% confidence interval, 64.0%–75.4%). rVE was consistent across subgroups and not modified by time since last monovalent dose or number of monovalent doses received. Protection was durable ≥3 months after the bivalent booster. rVE against SARS-CoV-2 infection requiring emergency department/urgent care and against COVID-19 hospital death was 55.0% (50.8%–58.8%) and 82.7% (63.7%–91.7%), respectively. The mRNA-1273 bivalent booster provides additional protection against hospitalization for COVID-19, medically attended SARS-CoV-2 infection, and COVID-19 hospital death.

Suggested Citation

  • Hung Fu Tseng & Bradley K. Ackerson & Lina S. Sy & Julia E. Tubert & Yi Luo & Sijia Qiu & Gina S. Lee & Katia J. Bruxvoort & Jennifer H. Ku & Ana Florea & Harpreet S. Takhar & Radha Bathala & Cindy Ke, 2023. "mRNA-1273 bivalent (original and Omicron) COVID-19 vaccine effectiveness against COVID-19 outcomes in the United States," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41537-7
    DOI: 10.1038/s41467-023-41537-7
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    2. Julia Stowe & Nick Andrews & Freja Kirsebom & Mary Ramsay & Jamie Lopez Bernal, 2022. "Effectiveness of COVID-19 vaccines against Omicron and Delta hospitalisation, a test negative case-control study," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
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