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Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents

Author

Listed:
  • Jaime S. Rosa Duque

    (The University of Hong Kong)

  • Xiwei Wang

    (The University of Hong Kong)

  • Daniel Leung

    (The University of Hong Kong)

  • Samuel M. S. Cheng

    (The University of Hong Kong)

  • Carolyn A. Cohen

    (The University of Hong Kong
    The University of Hong Kong)

  • Xiaofeng Mu

    (The University of Hong Kong)

  • Asmaa Hachim

    (The University of Hong Kong
    The University of Hong Kong
    University of Oxford)

  • Yanmei Zhang

    (The University of Hong Kong)

  • Sau Man Chan

    (The University of Hong Kong)

  • Sara Chaothai

    (The University of Hong Kong)

  • Kelvin K. H. Kwan

    (The University of Hong Kong)

  • Karl C. K. Chan

    (The University of Hong Kong)

  • John K. C. Li

    (The University of Hong Kong)

  • Leo L. H. Luk

    (The University of Hong Kong)

  • Leo C. H. Tsang

    (The University of Hong Kong)

  • Wilfred H. S. Wong

    (The University of Hong Kong)

  • Cheuk Hei Cheang

    (The University of Hong Kong)

  • Timothy K. Hung

    (The University of Hong Kong)

  • Jennifer H. Y. Lam

    (The University of Hong Kong)

  • Gilbert T. Chua

    (The University of Hong Kong)

  • Winnie W. Y. Tso

    (The University of Hong Kong
    The University of Hong Kong)

  • Patrick Ip

    (The University of Hong Kong)

  • Masashi Mori

    (Ishikawa Prefectural University)

  • Niloufar Kavian

    (The University of Hong Kong
    The University of Hong Kong
    IRCCS, Humanitas Research Hospital)

  • Wing Hang Leung

    (The University of Hong Kong)

  • Sophie Valkenburg

    (The University of Hong Kong
    The University of Hong Kong
    Peter Doherty Institute for Infection and Immunity, University of Melbourne)

  • Malik Peiris

    (The University of Hong Kong
    Centre for Immunology and Infection)

  • Wenwei Tu

    (The University of Hong Kong)

  • Yu Lung Lau

    (The University of Hong Kong)

Abstract

We present an interim analysis of a registered clinical study (NCT04800133) to establish immunobridging with various antibody and cellular immunity markers and to compare the immunogenicity and reactogenicity of 2-dose BNT162b2 and CoronaVac in healthy adolescents as primary objectives. One-dose BNT162b2, recommended in some localities for risk reduction of myocarditis, is also assessed. Antibodies and T cell immune responses are non-inferior or similar in adolescents receiving 2 doses of BNT162b2 (BB, N = 116) and CoronaVac (CC, N = 123) versus adults after 2 doses of the same vaccine (BB, N = 147; CC, N = 141) but not in adolescents after 1-dose BNT162b2 (B, N = 116). CC induces SARS-CoV-2 N and N C-terminal domain seropositivity in a higher proportion of adolescents than adults. Adverse reactions are mostly mild for both vaccines and more frequent for BNT162b2. We find higher S, neutralising, avidity and Fc receptor-binding antibody responses in adolescents receiving BB than CC, and a similar induction of strong S-specific T cells by the 2 vaccines, in addition to N- and M-specific T cells induced by CoronaVac but not BNT162b2, possibly implying differential durability and cross-variant protection by BNT162b2 and CoronaVac, the 2 most used SARS-CoV-2 vaccines worldwide. Our results support the use of both vaccines in adolescents.

Suggested Citation

  • Jaime S. Rosa Duque & Xiwei Wang & Daniel Leung & Samuel M. S. Cheng & Carolyn A. Cohen & Xiaofeng Mu & Asmaa Hachim & Yanmei Zhang & Sau Man Chan & Sara Chaothai & Kelvin K. H. Kwan & Karl C. K. Chan, 2022. "Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31485-z
    DOI: 10.1038/s41467-022-31485-z
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