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Cell-inspired design of cascade catalysis system by 3D spatially separated active sites

Author

Listed:
  • Qiuping Wang

    (University of Science and Technology of China
    University of Science and Technology of China)

  • Kui Chen

    (University of Science and Technology of China)

  • Hui Jiang

    (University of Science and Technology of China)

  • Cai Chen

    (University of Science and Technology of China)

  • Can Xiong

    (University of Science and Technology of China)

  • Min Chen

    (University of Science and Technology of China)

  • Jie Xu

    (Wenzhou University)

  • Xiaoping Gao

    (University of Science and Technology of China)

  • Suowen Xu

    (University of Science and Technology of China)

  • Huang Zhou

    (University of Science and Technology of China)

  • Yuen Wu

    (University of Science and Technology of China
    University of Science and Technology of China)

Abstract

Cells possess isolated compartments that spatially confine different enzymes, enabling high-efficiency enzymatic cascade reactions. Herein, we report a cell-inspired design of biomimetic cascade catalysis system by immobilizing Fe single atoms and Au nanoparticles on the inner and outer layers of three-dimensional nanocapsules, respectively. The different metal sites catalyze independently and work synergistically to enable engineered and cascade glucose detection. The biomimetic catalysis system demonstrates ~ 9.8- and 2-fold cascade activity enhancement than conventional mixing and coplanar construction systems, respectively. Furthermore, the biomimetic catalysis system is successfully demonstrated for the colorimetric glucose detection with high catalytic activity and selectivity. Also, the proposed gel-based sensor is integrated with smartphone to enable real-time and visual determination of glucose. More importantly, the gel-based sensor exhibits a high correlation with a commercial glucometer in real samples detection. These findings provide a strategy to design an efficient biomimetic catalysis system for applications in bioassays and nanobiomedicines.

Suggested Citation

  • Qiuping Wang & Kui Chen & Hui Jiang & Cai Chen & Can Xiong & Min Chen & Jie Xu & Xiaoping Gao & Suowen Xu & Huang Zhou & Yuen Wu, 2023. "Cell-inspired design of cascade catalysis system by 3D spatially separated active sites," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41002-5
    DOI: 10.1038/s41467-023-41002-5
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    References listed on IDEAS

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    1. Jinxing Chen & Qian Ma & Minghua Li & Daiyong Chao & Liang Huang & Weiwei Wu & Youxing Fang & Shaojun Dong, 2021. "Glucose-oxidase like catalytic mechanism of noble metal nanozymes," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
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