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Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

Author

Listed:
  • Qi Zhao

    (Sichuan University)

  • Man-Yun Dai

    (Sichuan University
    Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ruo-Yue Huang

    (Sichuan University)

  • Jing-Yi Duan

    (Sichuan University)

  • Ting Zhang

    (Sichuan University
    Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Wei-Min Bao

    (The First People’s Hospital of Yunnan Province)

  • Jing-Yi Zhang

    (The second Affiliated Hospital of Kunming Medical University)

  • Shao-Qiang Gui

    (The second Affiliated Hospital of Kunming Medical University)

  • Shu-Min Xia

    (The second Affiliated Hospital of Kunming Medical University)

  • Cong-Ting Dai

    (The second Affiliated Hospital of Kunming Medical University)

  • Ying-Mei Tang

    (The second Affiliated Hospital of Kunming Medical University)

  • Frank J. Gonzalez

    (National Institutes of Health)

  • Fei Li

    (Sichuan University
    Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Center, West China Hospital, Sichuan University)

Abstract

Parabacteroides distasonis (P. distasonis) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P. distasonis is decreased in patients with hepatic fibrosis, and that administration of P. distasonis to male mice improves thioacetamide (TAA)- and methionine and choline-deficient (MCD) diet-induced hepatic fibrosis. Administration of P. distasonis also leads to increased bile salt hydrolase (BSH) activity, inhibition of intestinal farnesoid X receptor (FXR) signaling and decreased taurochenodeoxycholic acid (TCDCA) levels in liver. TCDCA produces toxicity in mouse primary hepatic cells (HSCs) and induces mitochondrial permeability transition (MPT) and Caspase-11 pyroptosis in mice. The decrease of TCDCA by P. distasonis improves activation of HSCs through decreasing MPT-Caspase-11 pyroptosis in hepatocytes. Celastrol, a compound reported to increase P. distasonis abundance in mice, promotes the growth of P. distasonis with concomitant enhancement of bile acid excretion and improvement of hepatic fibrosis in male mice. These data suggest that supplementation of P. distasonis may be a promising means to ameliorate hepatic fibrosis.

Suggested Citation

  • Qi Zhao & Man-Yun Dai & Ruo-Yue Huang & Jing-Yi Duan & Ting Zhang & Wei-Min Bao & Jing-Yi Zhang & Shao-Qiang Gui & Shu-Min Xia & Cong-Ting Dai & Ying-Mei Tang & Frank J. Gonzalez & Fei Li, 2023. "Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37459-z
    DOI: 10.1038/s41467-023-37459-z
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    References listed on IDEAS

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    1. Yuko Sato & Koji Atarashi & Damian R. Plichta & Yasumichi Arai & Satoshi Sasajima & Sean M. Kearney & Wataru Suda & Kozue Takeshita & Takahiro Sasaki & Shoki Okamoto & Ashwin N. Skelly & Yuki Okamura , 2021. "Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians," Nature, Nature, vol. 599(7885), pages 458-464, November.
    2. Changtao Jiang & Cen Xie & Ying Lv & Jing Li & Kristopher W. Krausz & Jingmin Shi & Chad N. Brocker & Dhimant Desai & Shantu G. Amin & William H. Bisson & Yulan Liu & Oksana Gavrilova & Andrew D. Patt, 2015. "Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction," Nature Communications, Nature, vol. 6(1), pages 1-18, December.
    3. Shuo Han & Will Treuren & Curt R. Fischer & Bryan D. Merrill & Brian C. DeFelice & Juan M. Sanchez & Steven K. Higginbottom & Leah Guthrie & Lalla A. Fall & Dylan Dodd & Michael A. Fischbach & Justin , 2021. "A metabolomics pipeline for the mechanistic interrogation of the gut microbiome," Nature, Nature, vol. 595(7867), pages 415-420, July.
    4. Fei Li & Changtao Jiang & Kristopher W. Krausz & Yunfei Li & Istvan Albert & Haiping Hao & Kristin M. Fabre & James B. Mitchell & Andrew D. Patterson & Frank J. Gonzalez, 2013. "Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
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