Integrative genetic analysis illuminates ALS heritability and identifies risk genes
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DOI: 10.1038/s41467-022-35724-1
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- Yang I. Li & Garrett Wong & Jack Humphrey & Towfique Raj, 2019. "Prioritizing Parkinson’s disease genes using population-scale transcriptomic data," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
- Ke Zhang & Christopher J. Donnelly & Aaron R. Haeusler & Jonathan C. Grima & James B. Machamer & Peter Steinwald & Elizabeth L. Daley & Sean J. Miller & Kathleen M. Cunningham & Svetlana Vidensky & Sa, 2015. "The C9orf72 repeat expansion disrupts nucleocytoplasmic transport," Nature, Nature, vol. 525(7567), pages 56-61, September.
- Eric L. Nostrand & Peter Freese & Gabriel A. Pratt & Xiaofeng Wang & Xintao Wei & Rui Xiao & Steven M. Blue & Jia-Yu Chen & Neal A. L. Cody & Daniel Dominguez & Sara Olson & Balaji Sundararaman & Liju, 2020. "A large-scale binding and functional map of human RNA-binding proteins," Nature, Nature, vol. 583(7818), pages 711-719, July.
- X. Rosa Ma & Mercedes Prudencio & Yuka Koike & Sarat C. Vatsavayai & Garam Kim & Fred Harbinski & Adam Briner & Caitlin M. Rodriguez & Caiwei Guo & Tetsuya Akiyama & H. Broder Schmidt & Beryl B. Cummi, 2022. "TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A," Nature, Nature, vol. 603(7899), pages 124-130, March.
- Sven Niehues & Julia Bussmann & Georg Steffes & Ines Erdmann & Caroline Köhrer & Litao Sun & Marina Wagner & Kerstin Schäfer & Guangxia Wang & Sophia N. Koerdt & Morgane Stum & Sumit Jaiswal & Uttam L, 2015. "Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
- Anna-Leigh Brown & Oscar G. Wilkins & Matthew J. Keuss & Sarah E. Hill & Matteo Zanovello & Weaverly Colleen Lee & Alexander Bampton & Flora C. Y. Lee & Laura Masino & Yue A. Qi & Sam Bryce-Smith & Ar, 2022. "TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A," Nature, Nature, vol. 603(7899), pages 131-137, March.
- Monkol Lek & Konrad J. Karczewski & Eric V. Minikel & Kaitlin E. Samocha & Eric Banks & Timothy Fennell & Anne H. O’Donnell-Luria & James S. Ware & Andrew J. Hill & Beryl B. Cummings & Taru Tukiainen , 2016. "Analysis of protein-coding genetic variation in 60,706 humans," Nature, Nature, vol. 536(7616), pages 285-291, August.
- Dominik Niopek & Pierre Wehler & Julia Roensch & Roland Eils & Barbara Di Ventura, 2016. "Optogenetic control of nuclear protein export," Nature Communications, Nature, vol. 7(1), pages 1-9, April.
- Brian D. Freibaum & Yubing Lu & Rodrigo Lopez-Gonzalez & Nam Chul Kim & Sandra Almeida & Kyung-Ha Lee & Nisha Badders & Marc Valentine & Bruce L. Miller & Philip C. Wong & Leonard Petrucelli & Hong Jo, 2015. "GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport," Nature, Nature, vol. 525(7567), pages 129-133, September.
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