IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-022-35577-8.html
   My bibliography  Save this article

SREBP modulates the NADP+/NADPH cycle to control night sleep in Drosophila

Author

Listed:
  • Vittoria Mariano

    (University of Lausanne
    KU Leuven)

  • Alexandros K. Kanellopoulos

    (University of Lausanne)

  • Giuseppe Aiello

    (University of Lausanne)

  • Adrian C. Lo

    (University of Lausanne)

  • Eric Legius

    (KU Leuven)

  • Tilmann Achsel

    (University of Lausanne)

  • Claudia Bagni

    (University of Lausanne
    University of Rome “Tor Vergata”)

Abstract

Sleep behavior is conserved throughout evolution, and sleep disturbances are a frequent comorbidity of neuropsychiatric disorders. However, the molecular basis underlying sleep dysfunctions in neurological diseases remains elusive. Using a model for neurodevelopmental disorders (NDDs), the Drosophila Cytoplasmic FMR1 interacting protein haploinsufficiency (Cyfip85.1/+), we identify a mechanism modulating sleep homeostasis. We show that increased activity of the sterol regulatory element-binding protein (SREBP) in Cyfip85.1/+ flies induces an increase in the transcription of wakefulness-associated genes, such as the malic enzyme (Men), causing a disturbance in the daily NADP+/NADPH ratio oscillations and reducing sleep pressure at the night-time onset. Reduction in SREBP or Men activity in Cyfip85.1/+ flies enhances the NADP+/NADPH ratio and rescues the sleep deficits, indicating that SREBP and Men are causative for the sleep deficits in Cyfip heterozygous flies. This work suggests modulation of the SREBP metabolic axis as a new avenue worth exploring for its therapeutic potential in sleep disorders.

Suggested Citation

  • Vittoria Mariano & Alexandros K. Kanellopoulos & Giuseppe Aiello & Adrian C. Lo & Eric Legius & Tilmann Achsel & Claudia Bagni, 2023. "SREBP modulates the NADP+/NADPH cycle to control night sleep in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35577-8
    DOI: 10.1038/s41467-022-35577-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-35577-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-35577-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Shaun M. Purcell & Jennifer L. Moran & Menachem Fromer & Douglas Ruderfer & Nadia Solovieff & Panos Roussos & Colm O’Dushlaine & Kimberly Chambert & Sarah E. Bergen & Anna Kähler & Laramie Duncan & El, 2014. "A polygenic burden of rare disruptive mutations in schizophrenia," Nature, Nature, vol. 506(7487), pages 185-190, February.
    2. Nuria Domínguez-Iturza & Adrian C. Lo & Disha Shah & Marcelo Armendáriz & Anna Vannelli & Valentina Mercaldo & Massimo Trusel & Ka Wan Li & Denise Gastaldo & Ana Rita Santos & Zsuzsanna Callaerts-Vegh, 2019. "The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    3. Chiara Cirelli & Daniel Bushey & Sean Hill & Reto Huber & Robert Kreber & Barry Ganetzky & Giulio Tononi, 2005. "Reduced sleep in Drosophila Shaker mutants," Nature, Nature, vol. 434(7037), pages 1087-1092, April.
    4. Hreinn Stefansson & Dan Rujescu & Sven Cichon & Olli P. H. Pietiläinen & Andres Ingason & Stacy Steinberg & Ragnheidur Fossdal & Engilbert Sigurdsson & Thordur Sigmundsson & Jacobine E. Buizer-Voskamp, 2008. "Large recurrent microdeletions associated with schizophrenia," Nature, Nature, vol. 455(7210), pages 232-236, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Elaine T. Lim & Yingleong Chan & Pepper Dawes & Xiaoge Guo & Serkan Erdin & Derek J. C. Tai & Songlei Liu & Julia M. Reichert & Mannix J. Burns & Ying Kai Chan & Jessica J. Chiang & Katharina Meyer & , 2022. "Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Snaedis Kristmundsdottir & Hakon Jonsson & Marteinn T. Hardarson & Gunnar Palsson & Doruk Beyter & Hannes P. Eggertsson & Arnaldur Gylfason & Gardar Sveinbjornsson & Guillaume Holley & Olafur A. Stefa, 2023. "Sequence variants affecting the genome-wide rate of germline microsatellite mutations," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. McEvoy, Brian P. & Visscher, Peter M., 2009. "Genetics of human height," Economics & Human Biology, Elsevier, vol. 7(3), pages 294-306, December.
    4. Ralda Nehme & Olli Pietiläinen & Mykyta Artomov & Matthew Tegtmeyer & Vera Valakh & Leevi Lehtonen & Christina Bell & Tarjinder Singh & Aditi Trehan & John Sherwood & Danielle Manning & Emily Peirent , 2022. "The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    5. Rituparna Sinha & Sandip Samaddar & Rajat K De, 2015. "CNV-CH: A Convex Hull Based Segmentation Approach to Detect Copy Number Variations (CNV) Using Next-Generation Sequencing Data," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-22, August.
    6. Berk Mandiracioglu & Furkan Ozden & Gun Kaynar & Mehmet Alper Yilmaz & Can Alkan & A. Ercument Cicek, 2024. "ECOLE: Learning to call copy number variants on whole exome sequencing data," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    7. Yuni Kay & Linda Tsan & Elizabeth A. Davis & Chen Tian & Léa Décarie-Spain & Anastasiia Sadybekov & Anna N. Pushkin & Vsevolod Katritch & Scott E. Kanoski & Bruce E. Herring, 2022. "Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    8. Peter K Hatemi & Enda Byrne & Rose McDermott, 2012. "Introduction: What is a ‘gene’ and why does it matter for political science?," Journal of Theoretical Politics, , vol. 24(3), pages 305-327, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35577-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.