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A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors

Author

Listed:
  • Tao Jia

    (Xuzhou Medical University)

  • Ying-Di Wang

    (Xuzhou Medical University)

  • Jing Chen

    (Xuzhou Medical University)

  • Xue Zhang

    (Xuzhou Medical University)

  • Jun-Li Cao

    (Xuzhou Medical University
    Xuzhou Medical University
    Xuzhou Medical University)

  • Cheng Xiao

    (Xuzhou Medical University
    Xuzhou Medical University
    Xuzhou Medical University)

  • Chunyi Zhou

    (Xuzhou Medical University
    Xuzhou Medical University
    Xuzhou Medical University)

Abstract

The basal ganglia including the subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr) are involved in pain-related responses, but how they regulate pain processing remains unknown. Here, we identify a pathway, consisting of GABAergic neurons in the SNr (SNrGABA) and glutamatergic neurons in the STN (STNGlu) and the lateral parabrachial nucleus (LPBGlu), that modulates acute and persistent pain states in both male and female mice. The activity of STN neurons was enhanced in acute and persistent pain states. This enhancement was accompanied by hypoactivity in SNrGABA neurons and strengthening of the STN–LPB glutamatergic projection. Reversing the dysfunction in the SNrGABA-STNGlu-LPBGlu pathway attenuated activity of LPBGlu neurons and mitigated pain-like behaviors. Therefore, the SNrGABA-STNGlu-LPBGlu pathway regulates pathological pain and is a potential target for pain management.

Suggested Citation

  • Tao Jia & Ying-Di Wang & Jing Chen & Xue Zhang & Jun-Li Cao & Cheng Xiao & Chunyi Zhou, 2022. "A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35474-0
    DOI: 10.1038/s41467-022-35474-0
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    References listed on IDEAS

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    1. Li Sun & Rui Liu & Fang Guo & Man-qing Wen & Xiao-lin Ma & Kai-yuan Li & Hao Sun & Ceng-lin Xu & Yuan-yuan Li & Meng-yin Wu & Zheng-gang Zhu & Xin-jian Li & Yan-qin Yu & Zhong Chen & Xiang-yao Li & Sh, 2020. "Parabrachial nucleus circuit governs neuropathic pain-like behavior," Nature Communications, Nature, vol. 11(1), pages 1-21, December.
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    Cited by:

    1. Ya-Wei Ji & Zi-Lin Shen & Xue Zhang & Kairan Zhang & Tao Jia & Xiangying Xu & Huizhen Geng & Yu Han & Cui Yin & Jian-Jun Yang & Jun-Li Cao & Chunyi Zhou & Cheng Xiao, 2023. "Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Daniel G. Taub & Qiufen Jiang & Francesca Pietrafesa & Junfeng Su & Aloe Carroll & Caitlin Greene & Michael R. Blanchard & Aakanksha Jain & Mahmoud El-Rifai & Alexis Callen & Katherine Yager & Clara C, 2024. "The secondary somatosensory cortex gates mechanical and heat sensitivity," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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