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A Wolbachia factor for male killing in lepidopteran insects

Author

Listed:
  • Susumu Katsuma

    (The University of Tokyo)

  • Kanako Hirota

    (The University of Tokyo)

  • Noriko Matsuda-Imai

    (The University of Tokyo)

  • Takahiro Fukui

    (The University of Tokyo)

  • Tomohiro Muro

    (The University of Tokyo)

  • Kohei Nishino

    (Tokushima University)

  • Hidetaka Kosako

    (Tokushima University)

  • Keisuke Shoji

    (The University of Tokyo)

  • Hideki Takanashi

    (The University of Tokyo)

  • Takeshi Fujii

    (Setsunan University)

  • Shin-ichi Arimura

    (The University of Tokyo)

  • Takashi Kiuchi

    (The University of Tokyo)

Abstract

Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), an essential protein for masculinization and dosage compensation in lepidopteran insects. Here we identify a Wolbachia protein, designated Oscar, which interacts with Masc via its ankyrin repeats. Embryonic expression of Oscar inhibits Masc-induced masculinization and leads to male killing in two lepidopteran insects, O. furnacalis and the silkworm Bombyx mori. Our study identifies a mechanism by which Wolbachia induce male killing of host progeny.

Suggested Citation

  • Susumu Katsuma & Kanako Hirota & Noriko Matsuda-Imai & Takahiro Fukui & Tomohiro Muro & Kohei Nishino & Hidetaka Kosako & Keisuke Shoji & Hideki Takanashi & Takeshi Fujii & Shin-ichi Arimura & Takashi, 2022. "A Wolbachia factor for male killing in lepidopteran insects," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34488-y
    DOI: 10.1038/s41467-022-34488-y
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    References listed on IDEAS

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