IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-34462-8.html
   My bibliography  Save this article

Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma

Author

Listed:
  • Dongya Zhang

    (Henan University)

  • Sidan Tian

    (Huazhong University of Science and Technology)

  • Yanjie Liu

    (Henan University)

  • Meng Zheng

    (Henan University)

  • Xiangliang Yang

    (Huazhong University of Science and Technology)

  • Yan Zou

    (Henan University
    Macquarie University)

  • Bingyang Shi

    (Henan University
    Macquarie University)

  • Liang Luo

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

Glioblastoma multiforme (GBM) is one of the most fatal malignancies due to the existence of blood-brain barrier (BBB) and the difficulty to maintain an effective drug accumulation in deep GBM lesions. Here we present a biomimetic nanogel system that can be precisely activated by near infrared (NIR) irradiation to achieve BBB crossing and deep tumor penetration of drugs. Synthesized by crosslinking pullulan and poly(deca-4,6-diynedioic acid) (PDDA) and loaded with temozolomide and indocyanine green (ICG), the nanogels are inert to endogenous oxidative conditions but can be selectively disintegrated by ICG-generated reactive oxygen species upon NIR irradiation. Camouflaging the nanogels with apolipoprotein E peptide-decorated erythrocyte membrane further allows prolonged blood circulation and active tumor targeting. The precisely controlled NIR irradiation on tumor lesions excites ICG and deforms the cumulated nanogels to trigger burst drug release for facilitated BBB permeation and infiltration into distal tumor cells. These NIR-activatable biomimetic nanogels suppress the tumor growth in orthotopic GBM and GBM stem cells-bearing mouse models with significantly extended survival.

Suggested Citation

  • Dongya Zhang & Sidan Tian & Yanjie Liu & Meng Zheng & Xiangliang Yang & Yan Zou & Bingyang Shi & Liang Luo, 2022. "Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34462-8
    DOI: 10.1038/s41467-022-34462-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-34462-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-34462-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Alessandro Zorzi & Simon J. Middendorp & Jonas Wilbs & Kaycie Deyle & Christian Heinis, 2017. "Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    2. Benhao Li & Mengyao Zhao & Lishuai Feng & Chaoran Dou & Suwan Ding & Gang Zhou & Lingfei Lu & Hongxin Zhang & Feiya Chen & Xiaomin Li & Guangfeng Li & Shichang Zhao & Chunyu Jiang & Yan Wang & Dongyua, 2020. "Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sarun Juengpanich & Shijie Li & Taorui Yang & Tianao Xie & Jiadong Chen & Yukai Shan & Jiyoung Lee & Ziyi Lu & Tianen Chen & Bin Zhang & Jiasheng Cao & Jiahao Hu & Jicheng Yu & Yanfang Wang & Win Topa, 2023. "Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Lianghui Cheng & Zhiyong Zhuang & Mingming Yin & Yuan Lu & Sujuan Liu & Minle Zhan & Liyuan Zhao & Zhenyan He & Fanling Meng & Sidan Tian & Liang Luo, 2024. "A microenvironment-modulating dressing with proliferative degradants for the healing of diabetic wounds," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chao Mi & Xun Zhang & Chengyu Yang & Jianqun Wu & Xinxin Chen & Chenguang Ma & Sitong Wu & Zhichao Yang & Pengzhen Qiao & Yang Liu & Weijie Wu & Zhiyong Guo & Jiayan Liao & Jiajia Zhou & Ming Guan & C, 2023. "Bone disease imaging through the near-infrared-II window," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Jiajun Xu & Ningning Zhu & Yijing Du & Tianyang Han & Xue Zheng & Jia Li & Shoujun Zhu, 2024. "Biomimetic NIR-II fluorescent proteins created from chemogenic protein-seeking dyes for multicolor deep-tissue bioimaging," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Jeffrey Y. K. Wong & Arunika I. Ekanayake & Serhii Kharchenko & Steven E. Kirberger & Ryan Qiu & Payam Kelich & Susmita Sarkar & Jiaqian Li & Kleinberg X. Fernandez & Edgar R. Alvizo-Paez & Jiayuan Mi, 2023. "Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Rui Tian & Xin Feng & Long Wei & Daoguo Dai & Ying Ma & Haifeng Pan & Shengxiang Ge & Lang Bai & Chaomin Ke & Yanlin Liu & Lixin Lang & Shoujun Zhu & Haitao Sun & Yanbao Yu & Xiaoyuan Chen, 2022. "A genetic engineering strategy for editing near-infrared-II fluorophores," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Ashan Wijesinghe & Sarika Kumari & Valerie Booth, 2022. "Conjugates for use in peptide therapeutics: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(3), pages 1-19, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34462-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.