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Shared genetic risk factors and causal association between psoriasis and coronary artery disease

Author

Listed:
  • Matthew T. Patrick

    (University of Michigan)

  • Qinmengge Li

    (University of Michigan)

  • Rachael Wasikowski

    (University of Michigan)

  • Nehal Mehta

    (National Institutes of Health)

  • Johann E. Gudjonsson

    (University of Michigan)

  • James T. Elder

    (University of Michigan)

  • Xiang Zhou

    (University of Michigan)

  • Lam C. Tsoi

    (University of Michigan
    University of Michigan
    University of Michigan)

Abstract

Psoriasis and coronary artery disease (CAD) are related comorbidities that are well established, but whether a genetic basis underlies this is not well studied. We apply trans-disease meta-analysis to 11,024 psoriasis and 60,801 CAD cases, along with their associated controls, identifying one opposing and three shared genetic loci, which are confirmed through colocalization analysis. Combining results from Bayesian credible interval analysis with independent information from genomic, epigenomic, and spatial chromatin organization, we prioritize genes (including IFIH1 and IL23A) that have implications for common molecular mechanisms involved in psoriasis and CAD inflammatory signaling. Chronic systemic inflammation has been associated with CAD and myocardial infarction, and Mendelian randomization analysis finds that CAD as an exposure can have a significant causal effect on psoriasis (OR = 1.11; p = 3×10−6) following adjustment for BMI and waist-hip ratio. Together, these findings suggest that systemic inflammation which causes CAD can increase the risk of psoriasis.

Suggested Citation

  • Matthew T. Patrick & Qinmengge Li & Rachael Wasikowski & Nehal Mehta & Johann E. Gudjonsson & James T. Elder & Xiang Zhou & Lam C. Tsoi, 2022. "Shared genetic risk factors and causal association between psoriasis and coronary artery disease," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34323-4
    DOI: 10.1038/s41467-022-34323-4
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    1. Nick Dand & Philip E. Stuart & John Bowes & David Ellinghaus & Joanne Nititham & Jake R. Saklatvala & Maris Teder-Laving & Laurent F. Thomas & Tanel Traks & Steffen Uebe & Gunter Assmann & David Baudr, 2025. "GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets," Nature Communications, Nature, vol. 16(1), pages 1-14, December.

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