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Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci

Author

Listed:
  • Cindy Im

    (University of Minnesota)

  • Andrew R. Raduski

    (University of Minnesota)

  • Lauren J. Mills

    (University of Minnesota)

  • Kashi Raj Bhattarai

    (St. Jude Children’s Research Hospital)

  • Robert J. Mobley

    (St. Jude Children’s Research Hospital)

  • Kelly R. Barnett

    (St. Jude Children’s Research Hospital)

  • Zhanni Lu

    (University of Minnesota)

  • Kenneth Liao

    (University of Minnesota)

  • Nathan Anderson

    (University of Minnesota)

  • Rebecca A. Johnson

    (University of Minnesota)

  • Erica Langer

    (University of Minnesota)

  • Anthony J. Hooten

    (University of Minnesota)

  • Alix E. Seif

    (Children’s Hospital of Philadelphia)

  • Kathrin M. Bernt

    (Children’s Hospital of Philadelphia)

  • Matthew Tsang

    (Children’s Hospital of Philadelphia)

  • Brandon A. Mamou

    (Children’s Hospital of Philadelphia)

  • Luis Gil-de-Gómez

    (University of Cantabria-IDIVAL)

  • Julie A. Wolfson

    (University of Alabama at Birmingham)

  • Danielle N. Friedman

    (Memorial Sloan Kettering Cancer Center)

  • Neerav Shukla

    (Memorial Sloan Kettering Cancer Center)

  • Laura J. Klesse

    (University of Texas Southwestern Medical School)

  • Erin L. Marcotte

    (University of Minnesota)

  • Lingyun Ji

    (University of Southern California)

  • Alice Dang

    (Children’s Oncology Group)

  • Minjie Luo

    (Children’s Hospital of Philadelphia)

  • Yiming Zhong

    (Children’s Hospital of Philadelphia)

  • Jalen Langie

    (University of Southern California Keck School of Medicine)

  • Charleston W. K. Chiang

    (University of Southern California Keck School of Medicine)

  • Adam Smith

    (University of Southern California Keck School of Medicine)

  • Joseph L. Wiemels

    (University of Southern California Keck School of Medicine)

  • Andrew DeWan

    (Yale School of Public Health)

  • Xiaomei Ma

    (Yale School of Public Health)

  • Catherine Metayer

    (University of California)

  • Zhaoming Wang

    (St. Jude Children’s Research Hospital)

  • Heather H. Nelson

    (University of Minnesota)

  • Nathan Pankratz

    (University of Minnesota)

  • Tianzhong Yang

    (University of Minnesota)

  • Saonli Basu

    (University of Minnesota)

  • Lucie M. Turcotte

    (University of Minnesota)

  • Jun J. Yang

    (St. Jude Children’s Research Hospital)

  • Daniel Savic

    (St. Jude Children’s Research Hospital)

  • Michael E. Scheurer

    (Baylor College of Medicine
    Texas Children’s Hospital)

  • Logan G. Spector

    (University of Minnesota)

Abstract

B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric malignancy. Given racial/ethnic differences in incidence and outcomes, B-ALL genome-wide association studies among children of African ancestry are needed. Leveraging multi-institutional datasets with 840 African American children with B-ALL and 3360 controls, nine loci achieved genome-wide significance (P

Suggested Citation

  • Cindy Im & Andrew R. Raduski & Lauren J. Mills & Kashi Raj Bhattarai & Robert J. Mobley & Kelly R. Barnett & Zhanni Lu & Kenneth Liao & Nathan Anderson & Rebecca A. Johnson & Erica Langer & Anthony J., 2025. "Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64337-7
    DOI: 10.1038/s41467-025-64337-7
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    References listed on IDEAS

    as
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