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Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells

Author

Listed:
  • Mary-Ellen Lynall

    (University of Cambridge
    Cambridgeshire & Peterborough NHS Foundation Trust
    University of Cambridge Department of Medicine
    Wellcome Sanger Institute)

  • Blagoje Soskic

    (Wellcome Genome Campus
    Open Targets, Wellcome Genome Campus
    Human Technopole)

  • James Hayhurst

    (Open Targets, Wellcome Genome Campus)

  • Jeremy Schwartzentruber

    (Wellcome Genome Campus)

  • Daniel F. Levey

    (VA Connecticut Healthcare System
    Yale University School of Medicine)

  • Gita A. Pathak

    (VA Connecticut Healthcare System
    Yale University School of Medicine)

  • Renato Polimanti

    (VA Connecticut Healthcare System
    Yale University School of Medicine)

  • Joel Gelernter

    (VA Connecticut Healthcare System
    Yale University School of Medicine
    Yale University School of Medicine)

  • Murray B. Stein

    (VA San Diego Healthcare System
    University of California San Diego)

  • Gosia Trynka

    (Wellcome Genome Campus
    Open Targets, Wellcome Genome Campus)

  • Menna R. Clatworthy

    (University of Cambridge Department of Medicine
    Wellcome Sanger Institute)

  • Ed Bullmore

    (University of Cambridge
    Cambridgeshire & Peterborough NHS Foundation Trust)

Abstract

Multiple psychiatric disorders have been associated with abnormalities in both the innate and adaptive immune systems. The role of these abnormalities in pathogenesis, and whether they are driven by psychiatric risk variants, remains unclear. We test for enrichment of GWAS variants associated with multiple psychiatric disorders (cross-disorder or trans-diagnostic risk), or 5 specific disorders (cis-diagnostic risk), in regulatory elements in immune cells. We use three independent epigenetic datasets representing multiple organ systems and immune cell subsets. Trans-diagnostic and cis-diagnostic risk variants (for schizophrenia and depression) are enriched at epigenetically active sites in brain tissues and in lymphoid cells, especially stimulated CD4+ T cells. There is no evidence for enrichment of either trans-risk or cis-risk variants for schizophrenia or depression in myeloid cells. This suggests a possible model where environmental stimuli activate T cells to unmask the effects of psychiatric risk variants, contributing to the pathogenesis of mental health disorders.

Suggested Citation

  • Mary-Ellen Lynall & Blagoje Soskic & James Hayhurst & Jeremy Schwartzentruber & Daniel F. Levey & Gita A. Pathak & Renato Polimanti & Joel Gelernter & Murray B. Stein & Gosia Trynka & Menna R. Clatwor, 2022. "Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33885-7
    DOI: 10.1038/s41467-022-33885-7
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