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The importance of antimicrobial resistance in medical mycology

Author

Listed:
  • Neil A. R. Gow

    (University of Exeter, Geoffrey Pope Building)

  • Carolyn Johnson

    (Medical Research Council, Polaris House)

  • Judith Berman

    (Tel Aviv University)

  • Alix T. Coste

    (University Hospital Lausanne)

  • Christina A. Cuomo

    ((CAC) Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard)

  • David S. Perlin

    (Hackensack Meridian health)

  • Tihana Bicanic

    (St George’s University of London
    St George’s University Hospitals NHS Foundation Trust)

  • Thomas S. Harrison

    (University of Exeter, Geoffrey Pope Building
    St George’s University of London
    St George’s University Hospitals NHS Foundation Trust)

  • Nathan Wiederhold

    (University of Texas Health Science Center at San Antonio)

  • Mike Bromley

    (University of Manchester, CTF Building)

  • Tom Chiller

    (Center for Disease Control and Prevention Mycotic Disease Branch 1600 Clifton Rd, MSC-09)

  • Keegan Edgar

    (Center for Disease Control and Prevention Mycotic Disease Branch 1600 Clifton Rd, MSC-09)

Abstract

Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global health care priority. Some analyses, including the O’Neill report, have predicted that deaths due to drug-resistant bacterial infections may eclipse the total number of cancer deaths by 2050. Although fungal infections remain in the shadow of public awareness, total attributable annual deaths are similar to, or exceeds, global mortalities due to malaria, tuberculosis or HIV. The impact of fungal infections has been exacerbated by the steady rise of antifungal drug resistant strains and species which reflects the widespread use of antifungals for prophylaxis and therapy, and in the case of azole resistance in Aspergillus, has been linked to the widespread agricultural use of antifungals. This review, based on a workshop hosted by the Medical Research Council and the University of Exeter, illuminates the problem of antifungal resistance and suggests how this growing threat might be mitigated.

Suggested Citation

  • Neil A. R. Gow & Carolyn Johnson & Judith Berman & Alix T. Coste & Christina A. Cuomo & David S. Perlin & Tihana Bicanic & Thomas S. Harrison & Nathan Wiederhold & Mike Bromley & Tom Chiller & Keegan , 2022. "The importance of antimicrobial resistance in medical mycology," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32249-5
    DOI: 10.1038/s41467-022-32249-5
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    References listed on IDEAS

    as
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