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Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment

Author

Listed:
  • Yiyi Zhang

    (Huazhong University of Science and Technology)

  • Sidan Tian

    (Huazhong University of Science and Technology)

  • Liping Huang

    (Huazhong University of Science and Technology)

  • Yanan Li

    (China Pharmaceutical University
    Nanjing Normal University)

  • Yuan Lu

    (Huazhong University of Science and Technology)

  • Hongyu Li

    (Huazhong University of Science and Technology)

  • Guiping Chen

    (Bruker (Beijing) Scientific Technology Company Limited, Shanghai Branch)

  • Fanling Meng

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Gang L. Liu

    (Huazhong University of Science and Technology)

  • Xiangliang Yang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Jiasheng Tu

    (China Pharmaceutical University)

  • Chunmeng Sun

    (China Pharmaceutical University)

  • Liang Luo

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

Combining immune checkpoint blockade (ICB) therapy with photodynamic therapy (PDT) holds great potential in treating immunologically “cold” tumors, but photo-generated reactive oxygen species (ROS) can inevitably damage co-administered ICB antibodies, hence hampering the therapeutic outcome. Here we create a ROS-responsive hydrogel to realize the sustained co-delivery of photosensitizers and ICB antibodies. During PDT, the hydrogel skeleton poly(deca-4,6-diynedioic acid) (PDDA) protects ICB antibodies by scavenging the harmful ROS, and at the same time, triggers the gradual degradation of the hydrogel to release the drugs in a controlled manner. More interestingly, we can visualize the ROS-responsive hydrogel degradation by Raman imaging, given the ultrastrong and degradation-correlative Raman signal of PDDA in the cellular silent window. A single administration of the hydrogel not only completely inhibits the long-term postoperative recurrence and metastasis of 4T1-tumor-bearing mice, but also effectively restrains the growth of re-challenged tumors. The PDDA-based ROS-responsive hydrogel herein paves a promising way for the durable synergy of PDT and ICB therapy.

Suggested Citation

  • Yiyi Zhang & Sidan Tian & Liping Huang & Yanan Li & Yuan Lu & Hongyu Li & Guiping Chen & Fanling Meng & Gang L. Liu & Xiangliang Yang & Jiasheng Tu & Chunmeng Sun & Liang Luo, 2022. "Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32160-z
    DOI: 10.1038/s41467-022-32160-z
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    References listed on IDEAS

    as
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    Cited by:

    1. Danyu Wang & Jingwen Liu & Jie Duan & Hua Yi & Junjie Liu & Haiwei Song & Zhenzhong Zhang & Jinjin Shi & Kaixiang Zhang, 2023. "Enrichment and sensing tumor cells by embedded immunomodulatory DNA hydrogel to inhibit postoperative tumor recurrence," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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