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Olfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation

Author

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  • Anthony Renard

    (Institut Pasteur, INSERM, Institut de l’Audition
    UMR9197 CNRS/University Paris-Saclay, Campus CEA
    Laboratory of Sensory Processing, Brain Mind Institute)

  • Evan R. Harrell

    (Institut Pasteur, INSERM, Institut de l’Audition
    UMR9197 CNRS/University Paris-Saclay, Campus CEA
    Université de Bordeaux, Centre Broca Nouvelle-Aquitaine)

  • Brice Bathellier

    (Institut Pasteur, INSERM, Institut de l’Audition
    UMR9197 CNRS/University Paris-Saclay, Campus CEA)

Abstract

Rodents depend on olfaction and touch to meet many of their fundamental needs. However, the impact of simultaneous olfactory and tactile inputs on sensory representations in the cortex remains elusive. To study these interactions, we recorded large populations of barrel cortex neurons using 2-photon calcium imaging in head-fixed mice during olfactory and tactile stimulation. Here we show that odors bidirectionally alter activity in a small but significant population of barrel cortex neurons through at least two mechanisms, first by enhancing whisking, and second by a central mechanism that persists after whisking is abolished by facial nerve sectioning. Odor responses have little impact on tactile information, and they are sufficient for decoding odor identity, while behavioral parameters like whisking, sniffing, and facial movements are not odor identity-specific. Thus, barrel cortex activity encodes specific olfactory information that is not linked with odor-induced changes in behavior.

Suggested Citation

  • Anthony Renard & Evan R. Harrell & Brice Bathellier, 2022. "Olfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31565-0
    DOI: 10.1038/s41467-022-31565-0
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    References listed on IDEAS

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