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A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs

Author

Listed:
  • Yan Ting Shue

    (Stanford University
    Stanford University)

  • Alexandros P. Drainas

    (Stanford University
    Stanford University)

  • Nancy Yanzhe Li

    (Stanford University)

  • Sarah M. Pearsall

    (University of Manchester)

  • Derrick Morgan

    (University of Manchester)

  • Nasa Sinnott-Armstrong

    (Stanford University)

  • Susan Q. Hipkins

    (Stanford University
    Stanford University)

  • Garry L. Coles

    (Stanford University
    Stanford University)

  • Jing Shan Lim

    (Stanford University
    Stanford University)

  • Anthony E. Oro

    (Stanford University)

  • Kathryn L. Simpson

    (University of Manchester)

  • Caroline Dive

    (University of Manchester)

  • Julien Sage

    (Stanford University
    Stanford University)

Abstract

The Notch pathway is a conserved cell-cell communication pathway that controls cell fate decisions. Here we sought to determine how Notch pathway activation inhibits the neuroendocrine cell fate in the lungs, an archetypal process for cell fate decisions orchestrated by Notch signaling that has remained poorly understood at the molecular level. Using intratumoral heterogeneity in small-cell lung cancer as a tractable model system, we uncovered a role for the transcriptional regulators REST and YAP as promoters of the neuroendocrine to non-neuroendocrine transition. We further identified the specific neuroendocrine gene programs repressed by REST downstream of Notch in this process. Importantly, we validated the importance of REST and YAP in neuroendocrine to non-neuroendocrine cell fate switches in both developmental and tissue repair processes in the lungs. Altogether, these experiments identify conserved roles for REST and YAP in Notch-driven inhibition of the neuroendocrine cell fate in embryonic lungs, adult lungs, and lung cancer.

Suggested Citation

  • Yan Ting Shue & Alexandros P. Drainas & Nancy Yanzhe Li & Sarah M. Pearsall & Derrick Morgan & Nasa Sinnott-Armstrong & Susan Q. Hipkins & Garry L. Coles & Jing Shan Lim & Anthony E. Oro & Kathryn L. , 2022. "A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30416-2
    DOI: 10.1038/s41467-022-30416-2
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    References listed on IDEAS

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    1. Jing Shan Lim & Alvaro Ibaseta & Marcus M. Fischer & Belinda Cancilla & Gilbert O’Young & Sandra Cristea & Vincent C. Luca & Dian Yang & Nadine S. Jahchan & Cécile Hamard & Martine Antoine & Marie Wis, 2017. "Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer," Nature, Nature, vol. 545(7654), pages 360-364, May.
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    1. Zhengming Wu & Junhui Su & Fu-long Li & Tao Chen & Jaimie Mayner & Adam Engler & Shenghong Ma & Qingquan Li & Kun-Liang Guan, 2023. "YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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