IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-30162-5.html
   My bibliography  Save this article

Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants

Author

Listed:
  • Milja Belik

    (Institute of Biomedicine, University of Turku)

  • Pinja Jalkanen

    (Institute of Biomedicine, University of Turku)

  • Rickard Lundberg

    (Institute of Biomedicine, University of Turku)

  • Arttu Reinholm

    (Institute of Biomedicine, University of Turku)

  • Larissa Laine

    (Finnish Institute for Health and Welfare)

  • Elina Väisänen

    (Institute of Biomedicine, University of Turku
    Finnish Institute for Health and Welfare)

  • Marika Skön

    (Finnish Institute for Health and Welfare)

  • Paula A. Tähtinen

    (Turku University Hospital and University of Turku)

  • Lauri Ivaska

    (Turku University Hospital and University of Turku)

  • Sari H. Pakkanen

    (Helsinki University Hospital and University of Helsinki)

  • Hanni K. Häkkinen

    (Helsinki University Hospital and University of Helsinki)

  • Eeva Ortamo

    (Helsinki University Hospital and University of Helsinki)

  • Arja Pasternack

    (University of Helsinki)

  • Mikael A. Ritvos

    (University of Helsinki)

  • Rauno A. Naves

    (University of Helsinki)

  • Simo Miettinen

    (University of Helsinki and HUSLAB)

  • Tarja Sironen

    (University of Helsinki and HUSLAB
    University of Helsinki)

  • Olli Vapalahti

    (University of Helsinki and HUSLAB
    University of Helsinki)

  • Olli Ritvos

    (University of Helsinki)

  • Pamela Österlund

    (Finnish Institute for Health and Welfare)

  • Anu Kantele

    (Helsinki University Hospital and University of Helsinki)

  • Johanna Lempainen

    (Institute of Biomedicine, University of Turku
    Turku University Hospital and University of Turku
    Clinical Microbiology, Turku University Hospital)

  • Laura Kakkola

    (Institute of Biomedicine, University of Turku)

  • Pekka Kolehmainen

    (Institute of Biomedicine, University of Turku)

  • Ilkka Julkunen

    (Institute of Biomedicine, University of Turku
    Clinical Microbiology, Turku University Hospital)

Abstract

Two COVID-19 mRNA (of BNT162b2, mRNA-1273) and two adenovirus vector vaccines (ChAdOx1 and Janssen) are licensed in Europe, but optimization of regime and dosing is still ongoing. Here we show in health care workers (n = 328) that two doses of BNT162b2, mRNA-1273, or a combination of ChAdOx1 adenovirus vector and mRNA vaccines administrated with a long 12-week dose interval induce equally high levels of anti-SARS-CoV-2 spike antibodies and neutralizing antibodies against D614 and Delta variant. By contrast, two doses of BNT162b2 with a short 3-week interval induce 2-3-fold lower titers of neutralizing antibodies than those from the 12-week interval, yet a third BNT162b2 or mRNA-1273 booster dose increases the antibody levels 4-fold compared to the levels after the second dose, as well as induces neutralizing antibody against Omicron BA.1 variant. Our data thus indicates that a third COVID-19 mRNA vaccine may induce cross-protective neutralizing antibodies against multiple variants.

Suggested Citation

  • Milja Belik & Pinja Jalkanen & Rickard Lundberg & Arttu Reinholm & Larissa Laine & Elina Väisänen & Marika Skön & Paula A. Tähtinen & Lauri Ivaska & Sari H. Pakkanen & Hanni K. Häkkinen & Eeva Ortamo , 2022. "Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30162-5
    DOI: 10.1038/s41467-022-30162-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-30162-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-30162-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Bruno Pozzetto & Vincent Legros & Sophia Djebali & Véronique Barateau & Nicolas Guibert & Marine Villard & Loïc Peyrot & Omran Allatif & Jean-Baptiste Fassier & Amélie Massardier-Pilonchéry & Karen Br, 2021. "Immunogenicity and efficacy of heterologous ChAdOx1–BNT162b2 vaccination," Nature, Nature, vol. 600(7890), pages 701-706, December.
    2. Carolina Lucas & Chantal B. F. Vogels & Inci Yildirim & Jessica E. Rothman & Peiwen Lu & Valter Monteiro & Jeff R. Gehlhausen & Melissa Campbell & Julio Silva & Alexandra Tabachnikova & Mario A. Peña-, 2021. "Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity," Nature, Nature, vol. 600(7889), pages 523-529, December.
    3. Fabian Schmidt & Yiska Weisblum & Magdalena Rutkowska & Daniel Poston & Justin DaSilva & Fengwen Zhang & Eva Bednarski & Alice Cho & Dennis J. Schaefer-Babajew & Christian Gaebler & Marina Caskey & Mi, 2021. "High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape," Nature, Nature, vol. 600(7889), pages 512-516, December.
    4. Pinja Jalkanen & Pekka Kolehmainen & Hanni K. Häkkinen & Moona Huttunen & Paula A. Tähtinen & Rickard Lundberg & Sari Maljanen & Arttu Reinholm & Sisko Tauriainen & Sari H. Pakkanen & Iris Levonen & A, 2021. "COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    5. Alice Cho & Frauke Muecksch & Dennis Schaefer-Babajew & Zijun Wang & Shlomo Finkin & Christian Gaebler & Victor Ramos & Melissa Cipolla & Pilar Mendoza & Marianna Agudelo & Eva Bednarski & Justin DaSi, 2021. "Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination," Nature, Nature, vol. 600(7889), pages 517-522, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Laura Pérez-Alós & Jose Juan Almagro Armenteros & Johannes Roth Madsen & Cecilie Bo Hansen & Ida Jarlhelt & Sebastian Rask Hamm & Line Dam Heftdal & Mia Marie Pries-Heje & Dina Leth Møller & Kamille F, 2022. "Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Leander Witte & Viren A. Baharani & Fabian Schmidt & Zijun Wang & Alice Cho & Raphael Raspe & Camila Guzman-Cardozo & Frauke Muecksch & Marie Canis & Debby J. Park & Christian Gaebler & Marina Caskey , 2023. "Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Gudmundur L. Norddahl & Pall Melsted & Kristbjorg Gunnarsdottir & Gisli H. Halldorsson & Thorunn A. Olafsdottir & Arnaldur Gylfason & Mar Kristjansson & Olafur T. Magnusson & Patrick Sulem & Daniel F., 2022. "Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    4. Dapeng Li & David R. Martinez & Alexandra Schäfer & Haiyan Chen & Maggie Barr & Laura L. Sutherland & Esther Lee & Robert Parks & Dieter Mielke & Whitney Edwards & Amanda Newman & Kevin W. Bock & Mahn, 2022. "Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Grace Kenny & Sophie O’Reilly & Neil Wrigley Kelly & Riya Negi & Colette Gaillard & Dana Alalwan & Gurvin Saini & Tamara Alrawahneh & Nathan Francois & Matthew Angeliadis & Alejandro Abner Garcia Leon, 2023. "Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    6. Nadège Nziza & Yixiang Deng & Lianna Wood & Navneet Dhanoa & Naomi Dulit-Greenberg & Tina Chen & Abigail S. Kane & Zoe Swank & Jameson P. Davis & Melina Demokritou & Anagha P. Chitnis & Alessio Fasano, 2024. "Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    7. Andrew P. Hederman & Harini Natarajan & Leo Heyndrickx & Kevin K. Ariën & Joshua A. Wiener & Peter F. Wright & Evan M. Bloch & Aaron A. R. Tobian & Andrew D. Redd & Joel N. Blankson & Amihai Rottenstr, 2023. "SARS-CoV-2 vaccination elicits broad and potent antibody effector functions to variants of concern in vulnerable populations," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    8. David J. Sullivan & Massimo Franchini & Michael J. Joyner & Arturo Casadevall & Daniele Focosi, 2022. "Analysis of anti-SARS-CoV-2 Omicron-neutralizing antibody titers in different vaccinated and unvaccinated convalescent plasma sources," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    9. Jillian R. Jaycox & Carolina Lucas & Inci Yildirim & Yile Dai & Eric Y. Wang & Valter Monteiro & Sandra Lord & Jeffrey Carlin & Mariko Kita & Jane H. Buckner & Shuangge Ma & Melissa Campbell & Albert , 2023. "SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    10. Mingxi Li & Yifei Ren & Zhen Qin Aw & Bo Chen & Ziqing Yang & Yuqing Lei & Lin Cheng & Qingtai Liang & Junxian Hong & Yiling Yang & Jing Chen & Yi Hao Wong & Jing Wei & Sisi Shan & Senyan Zhang & Jiwa, 2022. "Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    11. Chaim A. Schramm & Damee Moon & Lowrey Peyton & Noemia S. Lima & Christian Wake & Kristin L. Boswell & Amy R. Henry & Farida Laboune & David Ambrozak & Samuel W. Darko & I-Ting Teng & Kathryn E. Fould, 2023. "Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    12. Georg M. N. Behrens & Joana Barros-Martins & Anne Cossmann & Gema Morillas Ramos & Metodi V. Stankov & Ivan Odak & Alexandra Dopfer-Jablonka & Laura Hetzel & Miriam Köhler & Gwendolyn Patzer & Christo, 2022. "BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    13. Kenneth Danh & Donna Grace Karp & Malvika Singhal & Akshaya Tankasala & David Gebhart & Felipe Jesus Cortez & Devangkumar Tandel & Peter V. Robinson & David Seftel & Mars Stone & Graham Simmons & Anil, 2022. "Detection of neutralizing antibodies against multiple SARS-CoV-2 strains in dried blood spots using cell-free PCR," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    14. Verena Klemis & Tina Schmidt & David Schub & Janine Mihm & Stefanie Marx & Amina Abu-Omar & Laura Ziegler & Franziska Hielscher & Candida Guckelmus & Rebecca Urschel & Stefan Wagenpfeil & Sophie Schne, 2022. "Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    15. Zhenhao Fang & Lei Peng & Renata Filler & Kazushi Suzuki & Andrew McNamara & Qianqian Lin & Paul A. Renauer & Luojia Yang & Bridget Menasche & Angie Sanchez & Ping Ren & Qiancheng Xiong & Madison Stri, 2022. "Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    16. Noemia S. Lima & Maryam Musayev & Timothy S. Johnston & Danielle A. Wagner & Amy R. Henry & Lingshu Wang & Eun Sung Yang & Yi Zhang & Kevina Birungi & Walker P. Black & Sijy O’Dell & Stephen D. Schmid, 2022. "Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    17. Lorenza Bellusci & Gabrielle Grubbs & Fatema Tuz Zahra & David Forgacs & Hana Golding & Ted M. Ross & Surender Khurana, 2022. "Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA.1, BA.2 and BA.3 following third mRNA vaccination," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    18. Eva-Maria Jacobsen & Dorit Fabricius & Magdalena Class & Fernando Topfstedt & Raquel Lorenzetti & Iga Janowska & Franziska Schmidt & Julian Staniek & Maria Zernickel & Thomas Stamminger & Andrea N. Di, 2022. "High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30162-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.