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Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

Author

Listed:
  • Xianyong Yin

    (University of Michigan School of Public Health)

  • Lap Sum Chan

    (University of Michigan School of Public Health)

  • Debraj Bose

    (University of Michigan School of Public Health)

  • Anne U. Jackson

    (University of Michigan School of Public Health)

  • Peter VandeHaar

    (University of Michigan School of Public Health)

  • Adam E. Locke

    (Washington University School of Medicine)

  • Christian Fuchsberger

    (University of Michigan School of Public Health
    Institute for Biomedicine, Eurac Research)

  • Heather M. Stringham

    (University of Michigan School of Public Health)

  • Ryan Welch

    (University of Michigan School of Public Health)

  • Ketian Yu

    (University of Michigan School of Public Health)

  • Lilian Fernandes Silva

    (University of Eastern Finland)

  • Susan K. Service

    (University of California Los Angeles)

  • Daiwei Zhang

    (University of Michigan School of Public Health
    University of Pennsylvania Perelman School of Medicine)

  • Emily C. Hector

    (North Carolina State University)

  • Erica Young

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Liron Ganel

    (Washington University School of Medicine)

  • Indraniel Das

    (Washington University School of Medicine)

  • Haley Abel

    (Washington University School of Medicine)

  • Michael R. Erdos

    (National Institutes of Health)

  • Lori L. Bonnycastle

    (National Institutes of Health)

  • Johanna Kuusisto

    (University of Eastern Finland
    Kuopio University Hospital)

  • Nathan O. Stitziel

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine)

  • Ira M. Hall

    (Yale University)

  • Gregory R. Wagner

    (Metabolon, Inc.)

  • Jian Kang

    (University of Michigan School of Public Health)

  • Jean Morrison

    (University of Michigan School of Public Health)

  • Charles F. Burant

    (University of Michigan)

  • Francis S. Collins

    (National Institutes of Health)

  • Samuli Ripatti

    (University of Helsinki
    University of Helsinki
    Broad Institute of MIT & Harvard)

  • Aarno Palotie

    (University of Helsinki
    University of Helsinki
    Massachusetts General Hospital)

  • Nelson B. Freimer

    (University of California Los Angeles)

  • Karen L. Mohlke

    (University of North Carolina at Chapel Hill)

  • Laura J. Scott

    (University of Michigan School of Public Health)

  • Xiaoquan Wen

    (University of Michigan School of Public Health)

  • Eric B. Fauman

    (Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical)

  • Markku Laakso

    (University of Eastern Finland)

  • Michael Boehnke

    (University of Michigan School of Public Health)

Abstract

Few studies have explored the impact of rare variants (minor allele frequency

Suggested Citation

  • Xianyong Yin & Lap Sum Chan & Debraj Bose & Anne U. Jackson & Peter VandeHaar & Adam E. Locke & Christian Fuchsberger & Heather M. Stringham & Ryan Welch & Ketian Yu & Lilian Fernandes Silva & Susan K, 2022. "Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29143-5
    DOI: 10.1038/s41467-022-29143-5
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    References listed on IDEAS

    as
    1. Lucas D. Ward & Ho-Chou Tu & Chelsea B. Quenneville & Shira Tsour & Alexander O. Flynn-Carroll & Margaret M. Parker & Aimee M. Deaton & Patrick A. J. Haslett & Luca A. Lotta & Niek Verweij & Manuel A., 2021. "GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Eugene P. Rhee & Qiong Yang & Bing Yu & Xuan Liu & Susan Cheng & Amy Deik & Kerry A. Pierce & Kevin Bullock & Jennifer E. Ho & Daniel Levy & Jose C. Florez & Sek Kathiresan & Martin G. Larson & Ramach, 2016. "An exome array study of the plasma metabolome," Nature Communications, Nature, vol. 7(1), pages 1-7, November.
    3. Adam E. Locke & Karyn Meltz Steinberg & Charleston W. K. Chiang & Susan K. Service & Aki S. Havulinna & Laurel Stell & Matti Pirinen & Haley J. Abel & Colby C. Chiang & Robert S. Fulton & Anne U. Jack, 2019. "Exome sequencing of Finnish isolates enhances rare-variant association power," Nature, Nature, vol. 572(7769), pages 323-328, August.
    4. Xiaoquan Wen & Roger Pique-Regi & Francesca Luca, 2017. "Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization," PLOS Genetics, Public Library of Science, vol. 13(3), pages 1-25, March.
    5. Jason Flannick & Josep M. Mercader & Christian Fuchsberger & Miriam S. Udler & Anubha Mahajan & Jennifer Wessel & Tanya M. Teslovich & Lizz Caulkins & Ryan Koesterer & Francisco Barajas-Olmos & Thomas, 2019. "Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls," Nature, Nature, vol. 570(7759), pages 71-76, June.
    6. Karsten Suhre & So-Youn Shin & Ann-Kristin Petersen & Robert P. Mohney & David Meredith & Brigitte Wägele & Elisabeth Altmaier & Panos Deloukas & Jeanette Erdmann & Elin Grundberg & Christopher J. Ham, 2011. "Human metabolic individuality in biomedical and pharmaceutical research," Nature, Nature, vol. 477(7362), pages 54-60, September.
    7. Christian Fuchsberger & Jason Flannick & Tanya M. Teslovich & Anubha Mahajan & Vineeta Agarwala & Kyle J. Gaulton & Clement Ma & Pierre Fontanillas & Loukas Moutsianas & Davis J. McCarthy & Manuel A. , 2016. "The genetic architecture of type 2 diabetes," Nature, Nature, vol. 536(7614), pages 41-47, August.
    8. Anshul Kundaje & Wouter Meuleman & Jason Ernst & Misha Bilenky & Angela Yen & Alireza Heravi-Moussavi & Pouya Kheradpour & Zhizhuo Zhang & Jianrong Wang & Michael J. Ziller & Viren Amin & John W. Whit, 2015. "Integrative analysis of 111 reference human epigenomes," Nature, Nature, vol. 518(7539), pages 317-330, February.
    9. Adam E. Locke & Karyn Meltz Steinberg & Charleston W. K. Chiang & Susan K. Service & Aki S. Havulinna & Laurel Stell & Matti Pirinen & Haley J. Abel & Colby C. Chiang & Robert S. Fulton & Anne U. Jack, 2019. "Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power," Nature, Nature, vol. 575(7783), pages 4-4, November.
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    Cited by:

    1. William R. Reay & Dylan J. Kiltschewskij & Maria A. Biase & Zachary F. Gerring & Kousik Kundu & Praveen Surendran & Laura A. Greco & Erin D. Clarke & Clare E. Collins & Alison M. Mondul & Demetrius Al, 2024. "Genetic influences on circulating retinol and its relationship to human health," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Linda Ottensmann & Rubina Tabassum & Sanni E. Ruotsalainen & Mathias J. Gerl & Christian Klose & Elisabeth Widén & Kai Simons & Samuli Ripatti & Matti Pirinen, 2023. "Genome-wide association analysis of plasma lipidome identifies 495 genetic associations," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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