IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-25366-0.html
   My bibliography  Save this article

Neural signatures of hyperdirect pathway activity in Parkinson’s disease

Author

Listed:
  • Ashwini Oswal

    (University of Oxford
    University of Oxford
    University College London)

  • Chunyan Cao

    (Shanghai JiaoTong University)

  • Chien-Hung Yeh

    (University of Oxford
    University of Oxford
    Beijing Institute of Technology)

  • Wolf-Julian Neumann

    (Charité University)

  • James Gratwicke

    (University College London)

  • Harith Akram

    (University College London)

  • Andreas Horn

    (Charité University)

  • Dianyou Li

    (Shanghai JiaoTong University)

  • Shikun Zhan

    (Shanghai JiaoTong University)

  • Chao Zhang

    (Shanghai JiaoTong University)

  • Qiang Wang

    (Charité University)

  • Ludvic Zrinzo

    (University College London)

  • Tom Foltynie

    (University College London)

  • Patricia Limousin

    (University College London)

  • Rafal Bogacz

    (University of Oxford
    University of Oxford)

  • Bomin Sun

    (Shanghai JiaoTong University)

  • Masud Husain

    (University of Oxford)

  • Peter Brown

    (University of Oxford
    University of Oxford)

  • Vladimir Litvak

    (University College London)

Abstract

Parkinson’s disease (PD) is characterised by the emergence of beta frequency oscillatory synchronisation across the cortico-basal-ganglia circuit. The relationship between the anatomy of this circuit and oscillatory synchronisation within it remains unclear. We address this by combining recordings from human subthalamic nucleus (STN) and internal globus pallidus (GPi) with magnetoencephalography, tractography and computational modelling. Coherence between supplementary motor area and STN within the high (21–30 Hz) but not low (13-21 Hz) beta frequency range correlated with ‘hyperdirect pathway’ fibre densities between these structures. Furthermore, supplementary motor area activity drove STN activity selectively at high beta frequencies suggesting that high beta frequencies propagate from the cortex to the basal ganglia via the hyperdirect pathway. Computational modelling revealed that exaggerated high beta hyperdirect pathway activity can provoke the generation of widespread pathological synchrony at lower beta frequencies. These findings suggest a spectral signature and a pathophysiological role for the hyperdirect pathway in PD.

Suggested Citation

  • Ashwini Oswal & Chunyan Cao & Chien-Hung Yeh & Wolf-Julian Neumann & James Gratwicke & Harith Akram & Andreas Horn & Dianyou Li & Shikun Zhan & Chao Zhang & Qiang Wang & Ludvic Zrinzo & Tom Foltynie &, 2021. "Neural signatures of hyperdirect pathway activity in Parkinson’s disease," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25366-0
    DOI: 10.1038/s41467-021-25366-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-25366-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-25366-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Leon A. Steiner & David Crompton & Srdjan Sumarac & Artur Vetkas & Jürgen Germann & Maximilian Scherer & Maria Justich & Alexandre Boutet & Milos R. Popovic & Mojgan Hodaie & Suneil K. Kalia & Alfonso, 2024. "Neural signatures of indirect pathway activity during subthalamic stimulation in Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Wang, Zhizhi & Hu, Bing & Zhou, Weiting & Xu, Minbo & Wang, Dingjiang, 2023. "Hopf bifurcation mechanism analysis in an improved cortex-basal ganglia network with distributed delays: An application to Parkinson’s disease," Chaos, Solitons & Fractals, Elsevier, vol. 166(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25366-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.