IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-24956-2.html
   My bibliography  Save this article

Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function

Author

Listed:
  • L. Grevendonk

    (Maastricht University
    TI Food and Nutrition)

  • N. J. Connell

    (Maastricht University
    TI Food and Nutrition)

  • C. McCrum

    (Maastricht University)

  • C. E. Fealy

    (Maastricht University
    TI Food and Nutrition)

  • L. Bilet

    (Maastricht University
    TI Food and Nutrition)

  • Y. M. H. Bruls

    (Maastricht University Medical Center+)

  • J. Mevenkamp

    (Maastricht University Medical Center+)

  • V. B. Schrauwen-Hinderling

    (Maastricht University
    Maastricht University Medical Center+)

  • J. A. Jörgensen

    (Maastricht University)

  • E. Moonen-Kornips

    (Maastricht University)

  • G. Schaart

    (Maastricht University)

  • B. Havekes

    (Maastricht University
    Maastricht University Medical Center+)

  • J. Vogel-van den Bosch

    (Danone Nutricia Research)

  • M. C. E. Bragt

    (Friesland-Campina)

  • K. Meijer

    (Maastricht University)

  • P. Schrauwen

    (Maastricht University
    TI Food and Nutrition)

  • J. Hoeks

    (Maastricht University
    TI Food and Nutrition)

Abstract

The relationship between the age-associated decline in mitochondrial function and its effect on skeletal muscle physiology and function remain unclear. In the current study, we examined to what extent physical activity contributes to the decline in mitochondrial function and muscle health during aging and compared mitochondrial function in young and older adults, with similar habitual physical activity levels. We also studied exercise-trained older adults and physically impaired older adults. Aging was associated with a decline in mitochondrial capacity, exercise capacity and efficiency, gait stability, muscle function, and insulin sensitivity, even when maintaining an adequate daily physical activity level. Our data also suggest that a further increase in physical activity level, achieved through regular exercise training, can largely negate the effects of aging. Finally, mitochondrial capacity correlated with exercise efficiency and insulin sensitivity. Together, our data support a link between mitochondrial function and age-associated deterioration of skeletal muscle.

Suggested Citation

  • L. Grevendonk & N. J. Connell & C. McCrum & C. E. Fealy & L. Bilet & Y. M. H. Bruls & J. Mevenkamp & V. B. Schrauwen-Hinderling & J. A. Jörgensen & E. Moonen-Kornips & G. Schaart & B. Havekes & J. Vog, 2021. "Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24956-2
    DOI: 10.1038/s41467-021-24956-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-24956-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-24956-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wang, Qiang & Zhang, Chen & Li, Rongrong, 2022. "Towards carbon neutrality by improving carbon efficiency - A system-GMM dynamic panel analysis for 131 countries’ carbon efficiency," Energy, Elsevier, vol. 258(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24956-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.