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Mitochondrial TCA cycle metabolites control physiology and disease

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  • Inmaculada Martínez-Reyes

    (Northwestern University Feinberg School of Medicine)

  • Navdeep S. Chandel

    (Northwestern University Feinberg School of Medicine
    Northwestern University Feinberg School of Medicine)

Abstract

Mitochondria are signaling organelles that regulate a wide variety of cellular functions and can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to the rest of the cell. Recent evidence confers a new role for TCA cycle intermediates, generally thought to be important for biosynthetic purposes, as signaling molecules with functions controlling chromatin modifications, DNA methylation, the hypoxic response, and immunity. This review summarizes the mechanisms by which the abundance of different TCA cycle metabolites controls cellular function and fate in different contexts. We will focus on how these metabolites mediated signaling can affect physiology and disease.

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  • Inmaculada Martínez-Reyes & Navdeep S. Chandel, 2020. "Mitochondrial TCA cycle metabolites control physiology and disease," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13668-3
    DOI: 10.1038/s41467-019-13668-3
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