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Evidence for allocentric boundary and goal direction information in the human entorhinal cortex and subiculum

Author

Listed:
  • J. P. Shine

    (Aging and Cognition Research Group)

  • J. P. Valdés-Herrera

    (Aging and Cognition Research Group)

  • C. Tempelmann

    (Otto-von-Guericke-University Magdeburg)

  • T. Wolbers

    (Aging and Cognition Research Group
    Otto-von-Guericke-University Magdeburg
    Center for Behavioral Brain Sciences)

Abstract

In rodents, cells in the medial entorhinal cortex (EC) and subiculum code for the allocentric direction to environment boundaries, which is an important prerequisite for accurate positional coding. Although in humans boundary-related signals have been reported, there is no evidence that they contain allocentric direction information. Furthermore, it has not been possible to separate boundary versus goal direction signals in the EC/subiculum. Here, to address these questions, we had participants learn a virtual environment containing four unique boundaries. Participants then underwent fMRI scanning where they made judgements about the allocentric direction of a cue object. Using multivariate decoding, we found information regarding allocentric boundary direction in posterior EC and subiculum, whereas allocentric goal direction was decodable from anterior EC and subiculum. These data provide the first evidence of allocentric boundary coding in humans, and are consistent with recent conceptualisations of a division of labour within the EC.

Suggested Citation

  • J. P. Shine & J. P. Valdés-Herrera & C. Tempelmann & T. Wolbers, 2019. "Evidence for allocentric boundary and goal direction information in the human entorhinal cortex and subiculum," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11802-9
    DOI: 10.1038/s41467-019-11802-9
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    Cited by:

    1. M. Jerome Beetz & Christian Kraus & Basil el Jundi, 2023. "Neural representation of goal direction in the monarch butterfly brain," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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