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The Role of Control Measures and the Environment in the Transmission Dynamics of Cholera

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  • Nicholas Kwasi-Do Ohene Opoku
  • Cecilia Afriyie

Abstract

Cholera is an infectious intestinal disease which occurs as a result of poor sanitation and lack of basic education in its transmission. It is characterized by profuse vomiting and severe diarrhea when an individual eats food or drinks water contaminated with the Vibrio cholerae . A dynamic mathematical model that explicitly simulates the transmission mechanism of cholera by taking into account the role of control measures and the environment in the transmission of the disease is developed. The model comprises two populations: the human population and bacteria population. The next-generation method is used to compute the basic reproduction number, . Both the disease-free and endemic equilibria are shown to be locally and globally stable for values less than unity and unstable otherwise. Necessary conditions of the optimal control problem were analyzed using Pontryagin’s maximum principle with control measures such as educational campaign and treatment of water bodies used to optimize the objective function. Numerical values of model parameters were estimated using the nonlinear least square method. The model simulations confirm the significant role played by control measures (education and treatment of water bodies) and the bacteria in the environment in the transmission dynamics as well as reducing the spread of cholera.

Suggested Citation

  • Nicholas Kwasi-Do Ohene Opoku & Cecilia Afriyie, 2020. "The Role of Control Measures and the Environment in the Transmission Dynamics of Cholera," Abstract and Applied Analysis, Hindawi, vol. 2020, pages 1-16, February.
    • Handle: RePEc:hin:jnlaaa:2485979
    DOI: 10.1155/2020/2485979
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    Cited by:

    1. Medda, Rakesh & Tiwari, Pankaj Kumar & Pal, Samares, 2024. "Impacts of planktonic components on the dynamics of cholera epidemic: Implications from a mathematical model," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 219(C), pages 505-526.
    2. Ohene Opoku, Nicholas Kwasi-Do & Bader, Georg & Fiatsonu, Edem, 2021. "Controlling crime with its associated cost during festive periods using mathematical techniques," Chaos, Solitons & Fractals, Elsevier, vol. 145(C).
    3. Nicholas Kwasi-Do Ohene Opoku & Reindorf Nartey Borkor & Andrews Frimpong Adu & Hannah Nyarkoah Nyarko & Albert Doughan & Edwin Moses Appiah & Biigba Yakubu & Isabel Mensah & Samson Pandam Salifu, 2022. "Modelling the Transmission Dynamics of Meningitis among High and Low‐Risk People in Ghana with Cost‐Effectiveness Analysis," Abstract and Applied Analysis, John Wiley & Sons, vol. 2022(1).
    4. Wahab A. Iddrisu & Inusah Iddrisu & Abdul-Karim Iddrisu, 2023. "Modeling Cholera Epidemiology Using Stochastic Differential Equations," Journal of Applied Mathematics, John Wiley & Sons, vol. 2023(1).

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