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Birth Defects in Gaza: Prevalence, Types, Familiarity and Correlation with Environmental Factors

Author

Listed:
  • Awny Naim

    (Palestinian Energy Authority, Gaza, Palestine)

  • Hedaya Al Dalies

    (Al Shifa Hospital, Gaza, Palestine)

  • Mohammed El Balawi

    (Al Shifa Hospital, Gaza, Palestine)

  • Eman Salem

    (Al Shifa Hospital, Gaza, Palestine)

  • Kholud Al Meziny

    (Al Shifa Hospital, Gaza, Palestine)

  • Raneem Al Shawwa

    (IT consultant, Gaza, Palestine)

  • Roberto Minutolo

    (Nephrology Department, University of Naples, Via Giovanni Paladino, 80138 Napoli, Italy)

  • Paola Manduca

    (Al Shifa Hospital, Gaza, Palestine
    Genetics Department, University of Genoa, C.Europa 26, 16132 Genova, Italy)

Abstract

This is the first report of registration at birth, and of incidence of major structural birth defects (BD) obtained in Gaza at Al Shifa Hospital, where 28% of total births in Gaza Strip occur. Doctors registered 4,027 deliveries, with a protocol comprehensive of clinical, demographic, kin and environmental questions. Prevalence of BD is 14/1,000, without association with intermarriage or gender of the child. Prevalence of late miscarriages and still births are respectively 23.3/1,000 and 7.4/1,000, and of premature births 19.6/1,000. Couples with a BD child have about 10 times higher frequency of recurrence of a BD in their progeny than those with normal children, but none of their 694 siblings and only 10/1,000 of their 1,423 progeny had BD, similar to the frequency in general population. These data suggest occurrence of novel genetic and epigenetic events in determination of BD. Children with BD were born with higher frequency ( p

Suggested Citation

  • Awny Naim & Hedaya Al Dalies & Mohammed El Balawi & Eman Salem & Kholud Al Meziny & Raneem Al Shawwa & Roberto Minutolo & Paola Manduca, 2012. "Birth Defects in Gaza: Prevalence, Types, Familiarity and Correlation with Environmental Factors," IJERPH, MDPI, vol. 9(5), pages 1-16, May.
    • Handle: RePEc:gam:jijerp:v:9:y:2012:i:5:p:1732-1747:d:17584
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    References listed on IDEAS

    as
    1. M. Azim Surani, 2001. "Reprogramming of genome function through epigenetic inheritance," Nature, Nature, vol. 414(6859), pages 122-128, November.
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    Cited by:

    1. Paola Manduca & Nabil Al Baraquni & Stefano Parodi, 2020. "Long Term Risks to Neonatal Health from Exposure to War—9 Years Long Survey of Reproductive Health and Contamination by Weapon-Delivered Heavy Metals in Gaza, Palestine," IJERPH, MDPI, vol. 17(7), pages 1-20, April.
    2. Nabil al Baraquoni & Samir R. Qouta & Mervi Vänskä & Safwat Y. Diab & Raija-Leena Punamäki & Paola Manduca, 2020. "It Takes Time to Unravel the Ecology of War in Gaza, Palestine: Long-Term Changes in Maternal, Newborn and Toddlers’ Heavy Metal Loads, and Infant and Toddler Developmental Milestones in the Aftermath," IJERPH, MDPI, vol. 17(18), pages 1-18, September.
    3. Paola Manduca & Awny Naim & Simona Signoriello, 2014. "Specific Association of Teratogen and Toxicant Metals in Hair of Newborns with Congenital Birth Defects or Developmentally Premature Birth in a Cohort of Couples with Documented Parental Exposure to M," IJERPH, MDPI, vol. 11(5), pages 1-16, May.
    4. Mauro Cristaldi & Cristiano Foschi & Germana Szpunar & Carlo Brini & Fiorenzo Marinelli & Lucio Triolo, 2013. "Toxic Emissions from a Military Test Site in the Territory of Sardinia, Italy," IJERPH, MDPI, vol. 10(4), pages 1-16, April.

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