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Diagnostic Accuracy of Differential-Diagnosis Lists Generated by Generative Pretrained Transformer 3 Chatbot for Clinical Vignettes with Common Chief Complaints: A Pilot Study

Author

Listed:
  • Takanobu Hirosawa

    (Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan)

  • Yukinori Harada

    (Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan)

  • Masashi Yokose

    (Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan)

  • Tetsu Sakamoto

    (Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan)

  • Ren Kawamura

    (Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan)

  • Taro Shimizu

    (Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan)

Abstract

The diagnostic accuracy of differential diagnoses generated by artificial intelligence (AI) chatbots, including the generative pretrained transformer 3 (GPT-3) chatbot (ChatGPT-3) is unknown. This study evaluated the accuracy of differential-diagnosis lists generated by ChatGPT-3 for clinical vignettes with common chief complaints. General internal medicine physicians created clinical cases, correct diagnoses, and five differential diagnoses for ten common chief complaints. The rate of correct diagnosis by ChatGPT-3 within the ten differential-diagnosis lists was 28/30 (93.3%). The rate of correct diagnosis by physicians was still superior to that by ChatGPT-3 within the five differential-diagnosis lists (98.3% vs. 83.3%, p = 0.03). The rate of correct diagnosis by physicians was also superior to that by ChatGPT-3 in the top diagnosis (53.3% vs. 93.3%, p < 0.001). The rate of consistent differential diagnoses among physicians within the ten differential-diagnosis lists generated by ChatGPT-3 was 62/88 (70.5%). In summary, this study demonstrates the high diagnostic accuracy of differential-diagnosis lists generated by ChatGPT-3 for clinical cases with common chief complaints. This suggests that AI chatbots such as ChatGPT-3 can generate a well-differentiated diagnosis list for common chief complaints. However, the order of these lists can be improved in the future.

Suggested Citation

  • Takanobu Hirosawa & Yukinori Harada & Masashi Yokose & Tetsu Sakamoto & Ren Kawamura & Taro Shimizu, 2023. "Diagnostic Accuracy of Differential-Diagnosis Lists Generated by Generative Pretrained Transformer 3 Chatbot for Clinical Vignettes with Common Chief Complaints: A Pilot Study," IJERPH, MDPI, vol. 20(4), pages 1-10, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3378-:d:1068780
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    References listed on IDEAS

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    1. Jiaming Zeng & Michael F. Gensheimer & Daniel L. Rubin & Susan Athey & Ross D. Shachter, 2022. "Uncovering interpretable potential confounders in electronic medical records," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Nicholas Riches & Maria Panagioti & Rahul Alam & Sudeh Cheraghi-Sohi & Stephen Campbell & Aneez Esmail & Peter Bower, 2016. "The Effectiveness of Electronic Differential Diagnoses (DDX) Generators: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-26, March.
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    Cited by:

    1. Arpan Kumar Kar & P. S. Varsha & Shivakami Rajan, 2023. "Unravelling the Impact of Generative Artificial Intelligence (GAI) in Industrial Applications: A Review of Scientific and Grey Literature," Global Journal of Flexible Systems Management, Springer;Global Institute of Flexible Systems Management, vol. 24(4), pages 659-689, December.
    2. Sarah Sandmann & Sarah Riepenhausen & Lucas Plagwitz & Julian Varghese, 2024. "Systematic analysis of ChatGPT, Google search and Llama 2 for clinical decision support tasks," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    3. Konstantinos I. Roumeliotis & Nikolaos D. Tselikas, 2023. "ChatGPT and Open-AI Models: A Preliminary Review," Future Internet, MDPI, vol. 15(6), pages 1-24, May.

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