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Metabolic Mechanism of Bacillus sp. LM24 under Abamectin Stress

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  • Yueping Zhu

    (College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China
    Guangdong Provincial Key Laboratory of Petrochemical Pollution Processes and Control, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, China)

  • Qilai Xie

    (College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China
    Guangdong Provincial Key Laboratory of Agricultural and Pural Pullution Abatement and Environmental Safety, Guangzhou 510642, China)

  • Jinshao Ye

    (Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, China)

  • Ruzhen Wang

    (Guangdong Provincial Key Laboratory of Petrochemical Pollution Processes and Control, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, China)

  • Xudong Yin

    (Guangdong Provincial Key Laboratory of Petrochemical Pollution Processes and Control, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, China)

  • Wenyu Xie

    (Guangdong Provincial Key Laboratory of Petrochemical Pollution Processes and Control, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, China)

  • Dehao Li

    (Guangdong Provincial Key Laboratory of Petrochemical Pollution Processes and Control, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, China)

Abstract

Abamectin (ABM) has been recently widely used in aquaculture. However, few studies have examined its metabolic mechanism and ecotoxicity in microorganisms. This study investigated the molecular metabolic mechanism and ecotoxicity of Bacillus sp. LM24 (B. sp LM24) under ABM stress using intracellular metabolomics. The differential metabolites most affected by the bacteria were lipids and lipid metabolites. The main significant metabolic pathways of B. sp LM24 in response to ABM stress were glycerolipid; glycine, serine, and threonine; and glycerophospholipid, and sphingolipid. The bacteria improved cell membrane fluidity and maintained cellular activity by enhancing the interconversion pathway of certain phospholipids and sn-3-phosphoglycerol. It obtained more extracellular oxygen and nutrients to adjust the lipid metabolism pathway, mitigate the impact of sugar metabolism, produce acetyl coenzyme A to enter the tricarboxylic acid (TCA) cycle, maintain sufficient anabolic energy, and use some amino acid precursors produced during the TCA cycle to express ABM efflux protein and degradative enzymes. It produced antioxidants, including hydroxyanigorufone, D-erythroascorbic acid 1′-a-D-xylopyranoside, and 3-methylcyclopentadecanone, to alleviate ABM-induced cellular and oxidative damage. However, prolonged stress can cause metabolic disturbances in the metabolic pathways of glycine, serine, threonine, and sphingolipid; reduce acetylcholine production; and increase quinolinic acid synthesis.

Suggested Citation

  • Yueping Zhu & Qilai Xie & Jinshao Ye & Ruzhen Wang & Xudong Yin & Wenyu Xie & Dehao Li, 2023. "Metabolic Mechanism of Bacillus sp. LM24 under Abamectin Stress," IJERPH, MDPI, vol. 20(4), pages 1-24, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3068-:d:1063432
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    References listed on IDEAS

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    1. Wenjin Hu & Xinli Pan & Hafiz Muhammad Khalid Abbas & Fengfeng Li & Wubei Dong, 2017. "Metabolites contributing to Rhizoctonia solani AG-1-IA maturation and sclerotial differentiation revealed by UPLC-QTOF-MS metabolomics," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-16, May.
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    1. Wenjin Hu & Xinli Pan & Fengfeng Li & Wubei Dong, 2018. "UPLC-QTOF-MS metabolomics analysis revealed the contributions of metabolites to the pathogenesis of Rhizoctonia solani strain AG-1-IA," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-17, February.

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