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Cadmium Body Burden and Inflammatory Arthritis: A Pilot Study in Patients from Lower Silesia, Poland

Author

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  • Iwona Markiewicz-Górka

    (Division of Environmental Health and Occupational Medicine, Department of Population Health, Wroclaw Medical University, 7 Mikulicza-Radeckiego St., 50-345 Wroclaw, Poland)

  • Małgorzata Chowaniec

    (Division of Environmental Health and Occupational Medicine, Department of Population Health, Wroclaw Medical University, 7 Mikulicza-Radeckiego St., 50-345 Wroclaw, Poland
    Department of Rheumatology and Internal Medicine, Wroclaw Medical University, 213 Borowska St., 50-556 Wroclaw, Poland)

  • Helena Martynowicz

    (Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 213 Borowska St., 50-556 Wroclaw, Poland)

  • Anna Wojakowska

    (Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 213 Borowska St., 50-556 Wroclaw, Poland)

  • Aleksandra Jaremków

    (Division of Environmental Health and Occupational Medicine, Department of Population Health, Wroclaw Medical University, 7 Mikulicza-Radeckiego St., 50-345 Wroclaw, Poland)

  • Grzegorz Mazur

    (Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 213 Borowska St., 50-556 Wroclaw, Poland)

  • Piotr Wiland

    (Department of Rheumatology and Internal Medicine, Wroclaw Medical University, 213 Borowska St., 50-556 Wroclaw, Poland)

  • Krystyna Pawlas

    (Division of Environmental Health and Occupational Medicine, Department of Population Health, Wroclaw Medical University, 7 Mikulicza-Radeckiego St., 50-345 Wroclaw, Poland)

  • Rafał Poręba

    (Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 213 Borowska St., 50-556 Wroclaw, Poland)

  • Paweł Gać

    (Division of Environmental Health and Occupational Medicine, Department of Population Health, Wroclaw Medical University, 7 Mikulicza-Radeckiego St., 50-345 Wroclaw, Poland)

Abstract

The purpose of this study was to determine the relationship between cadmium exposure and the likelihood of developing or exacerbating symptoms of inflammatory arthritis (IA). The study included 51 IA patients and 46 control subjects. Demographic and lifestyle data were collected. Haematological and biochemical parameters and blood cadmium levels (Cd-B) were determined. Cd-B correlated positively with age, smoking, living in a high-traffic area, and serum levels of inflammatory markers and negatively with mean corpuscular haemoglobin concentration (MCHC). The binary logistic regression model implied that high Cd-B (≥0.65 μg/L) is linked with an increased risk of IA in the studied population (odds ratio: 4.4). High levels of DNA oxidative damage marker (8-hydroxy-2’-deoxyguanosine) (≥7.66 ng/mL) and cyclooxygenase-2 (≥22.9 ng/mL) and frequent consumption of offal was also associated with increased risk of IA. High Cd-B was related to increased risk of disease symptoms onset in the group of IA patients, decreased the level of interleukin 10, and positively correlated with the disease activity. Increased Cd-B is associated with intensified inflammatory processes and decreased haemoglobin levels; in IA patients with decreased anti-inflammatory interleukin 10. These changes partly explain why cadmium exposure and a high cadmium body burden may raise the risk of IA and of disease symptoms exacerbation.

Suggested Citation

  • Iwona Markiewicz-Górka & Małgorzata Chowaniec & Helena Martynowicz & Anna Wojakowska & Aleksandra Jaremków & Grzegorz Mazur & Piotr Wiland & Krystyna Pawlas & Rafał Poręba & Paweł Gać, 2022. "Cadmium Body Burden and Inflammatory Arthritis: A Pilot Study in Patients from Lower Silesia, Poland," IJERPH, MDPI, vol. 19(5), pages 1-19, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:5:p:3099-:d:765257
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    References listed on IDEAS

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    1. Junhyeong Lee & Wanhyung Lee & Won-Jun Choi & Seong-Kyu Kang & Seunghon Ham, 2019. "Association between Exposure to Extreme Temperature and Injury at the Workplace," IJERPH, MDPI, vol. 16(24), pages 1-10, December.
    2. Giuseppe Genchi & Maria Stefania Sinicropi & Graziantonio Lauria & Alessia Carocci & Alessia Catalano, 2020. "The Effects of Cadmium Toxicity," IJERPH, MDPI, vol. 17(11), pages 1-24, May.
    3. Chang Liu & Yaohui Zhu & Zhenxiang Lu & Weina Guo & Bayaer Tumen & Yalan He & Chao Chen & Shanshan Hu & Kangzhi Xu & Yan Wang & Lei Li & Shenghe Li, 2019. "Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway," IJERPH, MDPI, vol. 17(1), pages 1-10, December.
    4. Jiyoung Shin & Jiyoung Lee & Jueun Lee & Eun-Hee Ha, 2019. "Association between Exposure to Ambient Air Pollution and Rheumatoid Arthritis in Adults," IJERPH, MDPI, vol. 16(7), pages 1-10, April.
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