IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i2p976-d725853.html
   My bibliography  Save this article

Levels of Trace Elements in Erythrocytes as Endocrine Disruptors in Obese and Nonobese Women with Polycystic Ovary Syndrome

Author

Listed:
  • Kamila Pokorska-Niewiada

    (Department of Toxicology, Dairy Technology and Food Storage, West Pomeranian University of Technology in Szczecin, 71-374 Szczecin, Poland)

  • Agnieszka Brodowska

    (Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland)

  • Jacek Brodowski

    (Primary Care Department, Pomeranian Medical University in Szczecin, Żołnierska 48, 71-210 Szczecin, Poland)

  • Małgorzata Szczuko

    (Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland)

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is one of the most commonly recognized endocrinopathies in women. The literature lacks clear data that allow any meaningful conclusions to be drawn about the influence of trace elements in erythrocytes on the biochemical parameters of PCOS. Materials and methods: This study was conducted among 47 women meeting the Rotterdam criteria for the diagnosis of polycystic ovary syndrome. The research groups included women with PCOS with different BMI values (body mass index): obese women with PCOS (PCOS with BMI ≥ 30, mean BMI index 35.4 ± 4.4 kg/m 2 ), nonobese PCOS women (PCOS with BMI < 30, mean BMI index 25.2 ± 2.8 kg/m 2 ), and healthy control group (CG) with a mean BMI of 23.57 ± 0.9 kg/m 2 . The contents of trace elements in erythrocytes were determined with an inductively coupled plasma atomic emission spectrometer. Results: The only trace element showing significant differences in concentration between the studied groups was nickel (Ni). The level of nickel in the obese women with PCOS (BMI ≥ 30) was significantly higher than in nonobese women (BMI < 30). The content of other trace elements in erythrocytes did not differ significantly between the studied groups. Several significant correlations were found within each of the studied PCOS groups: in the group of obese women, the content of zinc (Zn) in erythrocytes positively correlated with prolactin, the content of magnesium (Mg) positively correlated with testosterone, and the content of manganese (Mn) negatively correlated with thyroid-stimulating hormone. In the group of nonobese women, Zn content correlated positively with testosterone, Ni with luteinizing hormone (LH) and estradiol, and Mg negatively correlated with estradiol. Conclusions: The relationship between the level of trace elements and the level of hormones suggests that, in obese women with PCOS, nickel may play a role in inhibiting the processes of folliculogenesis and ovulation. Research on trace elements and their relationship to ovulatory cycles and the development of PCOS may contribute to reducing the consequences of PCOS and, therefore, should be extended.

Suggested Citation

  • Kamila Pokorska-Niewiada & Agnieszka Brodowska & Jacek Brodowski & Małgorzata Szczuko, 2022. "Levels of Trace Elements in Erythrocytes as Endocrine Disruptors in Obese and Nonobese Women with Polycystic Ovary Syndrome," IJERPH, MDPI, vol. 19(2), pages 1-12, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:976-:d:725853
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/2/976/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/2/976/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Miguel A. Padilla & Mai Elobeid & Douglas M. Ruden & David B. Allison, 2010. "An Examination of the Association of Selected Toxic Metals with Total and Central Obesity Indices: NHANES 99-02," IJERPH, MDPI, vol. 7(9), pages 1-16, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Antonio Sarría-Santamera & Antonio Simone Laganà & Milan Terzic, 2022. "Women’s Health and Gynecology: Old Challenges and New Insights," IJERPH, MDPI, vol. 19(24), pages 1-6, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Beatrice Campanella & Laura Colombaioni & Edoardo Benedetti & Agostino Di Ciaula & Lisa Ghezzi & Massimo Onor & Massimo D’Orazio & Roberto Giannecchini & Riccardo Petrini & Emilia Bramanti, 2019. "Toxicity of Thallium at Low Doses: A Review," IJERPH, MDPI, vol. 16(23), pages 1-6, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:976-:d:725853. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.