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Stimulation of the Vascular Endothelium and Angiogenesis by Blood-Flow-Restricted Exercise

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  • Mikołaj Maga

    (Department of Rehabilitation in Internal Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Krakow, Poland
    Clinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, Poland)

  • Martyna Schönborn

    (Clinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, Poland
    Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland)

  • Agnieszka Wachsmann-Maga

    (Clinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, Poland
    Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland)

  • Agnieszka Śliwka

    (Department of Rehabilitation in Internal Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Krakow, Poland)

  • Jakub Krężel

    (Clinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, Poland)

  • Aleksandra Włodarczyk

    (Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland)

  • Marta Olszewska

    (Department of Pediatrics, Institute of Pediatrics, Faculty of Medicine, Jagiellonian University Medical College, 30-663 Krakow, Poland)

  • Roman Nowobilski

    (Department of Rehabilitation in Internal Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Krakow, Poland)

Abstract

Blood-flow-restricted exercise (BFRE) has been gaining constantly increasing interest in rehabilitation, but its influence on endothelial functions has not been well studied yet. Our aim is to examine the influence of low-resistance BFRE on endothelial functions and angiogenesis. This prospective cross-over study involved 35 young healthy adults. They conducted a 21-min low-resistant exercise with blood flow restricted by pressure cuffs placed on arms and tights. They also did the same training but without blood flow restriction. Endothelial parameters and angiogenesis biomarkers were evaluated before and up to 20 min after exercise. Both types of exercise increased Flow-Mediated Dilatation (FMD) but elevation after BFRE was more significant compared to the controls. The stiffness index decreased only after BFRE, while the reflection index decreased significantly after both types of exercise but was higher after BFRE. Platelet endothelial cell adhesion molecule (PECAM-1) and vascular endothelial growth factor receptor 2 (VEGFR-2) concentrations were increased by both exercise types but elevations were higher after BFRE compared to the controls. Only BFRE elevated the mean serum CD34 protein concentration. Based on these results, we can assume that low-resistance BFR exercise stimulates angiogenesis and improves endothelial functions more significantly compared to the same training performed without blood flow restriction.

Suggested Citation

  • Mikołaj Maga & Martyna Schönborn & Agnieszka Wachsmann-Maga & Agnieszka Śliwka & Jakub Krężel & Aleksandra Włodarczyk & Marta Olszewska & Roman Nowobilski, 2022. "Stimulation of the Vascular Endothelium and Angiogenesis by Blood-Flow-Restricted Exercise," IJERPH, MDPI, vol. 19(23), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:23:p:15859-:d:987139
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    References listed on IDEAS

    as
    1. Tianqi Zhang & Guixian Tian & Xing Wang, 2022. "Effects of Low-Load Blood Flow Restriction Training on Hemodynamic Responses and Vascular Function in Older Adults: A Meta-Analysis," IJERPH, MDPI, vol. 19(11), pages 1-19, May.
    2. Lee J. Winchester & Morgan T. Blake & Abby R. Fleming & Elroy J. Aguiar & Michael V. Fedewa & Michael R. Esco & Ryan L. Earley, 2022. "Hemodynamic Responses to Resistance Exercise with Blood Flow Restriction Using a Practical Method Versus a Traditional Cuff-Inflation System," IJERPH, MDPI, vol. 19(18), pages 1-13, September.
    3. Fabiano Aparecido Pinheiro & Flávio Oliveira Pires & Bent R. Rønnestad & Felipe Hardt & Miguel Soares Conceição & Manoel E. Lixandrão & Ricardo Berton & Valmor Tricoli, 2022. "The Effect of Low-intensity Aerobic Training Combined with Blood Flow Restriction on Maximal Strength, Muscle Mass, and Cycling Performance in a Cyclist with Knee Displacement," IJERPH, MDPI, vol. 19(5), pages 1-7, March.
    4. Monika Starzak & Agata Stanek & Grzegorz K. Jakubiak & Armand Cholewka & Grzegorz Cieślar, 2022. "Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?," IJERPH, MDPI, vol. 19(16), pages 1-14, August.
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    Cited by:

    1. Shufan Li & Peng Wang & Xin Xin & Xiaojing Zhou & Jing Wang & Jinlei Zhao & Xing Wang, 2023. "The Effect of Low Intensity Resistance Training with Blood Flow Restriction on Fall Resistance in Middle-Aged and Older Adults: A Meta-Analysis," IJERPH, MDPI, vol. 20(6), pages 1-15, March.

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