IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i21p13898-d953391.html
   My bibliography  Save this article

Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study

Author

Listed:
  • Geraldo A. Maranhao Neto

    (International Clinical Research Center (ICRC), St Anne’s University Hospital (FNUSA) Brno, 602 00 Brno, Czech Republic)

  • Anna Bartoskova Polcrova

    (International Clinical Research Center (ICRC), St Anne’s University Hospital (FNUSA) Brno, 602 00 Brno, Czech Republic
    Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic)

  • Anna Pospisilova

    (International Clinical Research Center (ICRC), St Anne’s University Hospital (FNUSA) Brno, 602 00 Brno, Czech Republic)

  • Ludek Blaha

    (Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic)

  • Jana Klanova

    (Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic)

  • Martin Bobak

    (Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic)

  • Juan P. Gonzalez-Rivas

    (International Clinical Research Center (ICRC), St Anne’s University Hospital (FNUSA) Brno, 602 00 Brno, Czech Republic
    Foundation for Clinic, Public Health, and Epidemiology Research of Venezuela (FISPEVEN INC), Caracas 3001, Venezuela
    Department of Global Health and Population, Harvard TH Chan School of Public Health, Harvard University, Boston, MA 02138, USA)

Abstract

Even though there is evidence of decreasing trends of per- and polyfluoroalkyl substances (PFAS) in Czechia, there are still major sources of PFAS pollution. Regarding the still-inconsistent results of the relationship between cardiometabolic health and PFAS, the present study sought to determine the association between PFAS levels and the presence of cardiometabolic biomarkers, including blood pressure and dysglycemia drivers in the Czech population. A cross-sectional study with 479 subjects (56.4% women, median: 53 years, range: 25–89) was conducted. Four PFAS were measured in serum: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorooctane sulfonate (PFOS). The associations between natural log (ln)-transformed PFAS and cardiometabolic biomarkers were assessed through generalized additive models using linear regression and smoothing thin plate splines, adjusted for potential confounders. There were positive and significant ( p < 0.05) associations between the ln-transformed PFOA and glucose (β = 0.01), systolic (β = 0.76) and diastolic blood pressure (β = 0.65); total cholesterol (β = 0.07) and LDL-c (β = 0.04); and PFOS with glucose (β = 0.03), BMI (β = 2.26), waist circumference (β = 7.89), systolic blood pressure (β = 1.18), total cholesterol (β = 0.13), and HDL-c (β = 0.04). When significant, the correlations of PFNA and PFDA were negative. Of the four PFAS, only PFOA and PFOS showed a positive association, even in serum levels not as high as the values from the literature.

Suggested Citation

  • Geraldo A. Maranhao Neto & Anna Bartoskova Polcrova & Anna Pospisilova & Ludek Blaha & Jana Klanova & Martin Bobak & Juan P. Gonzalez-Rivas, 2022. "Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study," IJERPH, MDPI, vol. 19(21), pages 1-10, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:13898-:d:953391
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/21/13898/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/21/13898/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Tahir Bashir & Emmanuel Obeng-Gyasi, 2022. "The Association between Multiple Per- and Polyfluoroalkyl Substances’ Serum Levels and Allostatic Load," IJERPH, MDPI, vol. 19(9), pages 1-12, April.
    2. Maryam Zare Jeddi & Teresa Dalla Zuanna & Giulia Barbieri & Aline S. C. Fabricio & Francesca Daprà & Tony Fletcher & Francesca Russo & Gisella Pitter & Cristina Canova, 2021. "Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy," IJERPH, MDPI, vol. 18(3), pages 1-18, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nilisha Khadgi Sonnenberg & Akinloye Emmanuel Ojewole & Catherine Oluwalopeye Ojewole & Otite Precious Lucky & Joseph Kusi, 2023. "Trends in Serum Per- and Polyfluoroalkyl Substance (PFAS) Concentrations in Teenagers and Adults, 1999–2018 NHANES," IJERPH, MDPI, vol. 20(21), pages 1-14, October.
    2. Tahir Bashir & Emmanuel Obeng-Gyasi, 2023. "Combined Effects of Multiple Per- and Polyfluoroalkyl Substances Exposure on Allostatic Load Using Bayesian Kernel Machine Regression," IJERPH, MDPI, vol. 20(10), pages 1-22, May.
    3. Tahir Bashir & Fafanyo Asiseh & Kenrett Jefferson-Moore & Emmanuel Obeng-Gyasi, 2022. "The Association of Per- and Polyfluoroalkyl Substances Serum Levels and Allostatic Load by Country of Birth and the Length of Time in the United States," IJERPH, MDPI, vol. 19(15), pages 1-11, August.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:13898-:d:953391. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.