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Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study

Author

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  • Geraldo A. Maranhao Neto

    (International Clinical Research Center (ICRC), St Anne’s University Hospital (FNUSA) Brno, 602 00 Brno, Czech Republic)

  • Anna Bartoskova Polcrova

    (International Clinical Research Center (ICRC), St Anne’s University Hospital (FNUSA) Brno, 602 00 Brno, Czech Republic
    Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic)

  • Anna Pospisilova

    (International Clinical Research Center (ICRC), St Anne’s University Hospital (FNUSA) Brno, 602 00 Brno, Czech Republic)

  • Ludek Blaha

    (Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic)

  • Jana Klanova

    (Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic)

  • Martin Bobak

    (Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic)

  • Juan P. Gonzalez-Rivas

    (International Clinical Research Center (ICRC), St Anne’s University Hospital (FNUSA) Brno, 602 00 Brno, Czech Republic
    Foundation for Clinic, Public Health, and Epidemiology Research of Venezuela (FISPEVEN INC), Caracas 3001, Venezuela
    Department of Global Health and Population, Harvard TH Chan School of Public Health, Harvard University, Boston, MA 02138, USA)

Abstract

Even though there is evidence of decreasing trends of per- and polyfluoroalkyl substances (PFAS) in Czechia, there are still major sources of PFAS pollution. Regarding the still-inconsistent results of the relationship between cardiometabolic health and PFAS, the present study sought to determine the association between PFAS levels and the presence of cardiometabolic biomarkers, including blood pressure and dysglycemia drivers in the Czech population. A cross-sectional study with 479 subjects (56.4% women, median: 53 years, range: 25–89) was conducted. Four PFAS were measured in serum: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorooctane sulfonate (PFOS). The associations between natural log (ln)-transformed PFAS and cardiometabolic biomarkers were assessed through generalized additive models using linear regression and smoothing thin plate splines, adjusted for potential confounders. There were positive and significant ( p < 0.05) associations between the ln-transformed PFOA and glucose (β = 0.01), systolic (β = 0.76) and diastolic blood pressure (β = 0.65); total cholesterol (β = 0.07) and LDL-c (β = 0.04); and PFOS with glucose (β = 0.03), BMI (β = 2.26), waist circumference (β = 7.89), systolic blood pressure (β = 1.18), total cholesterol (β = 0.13), and HDL-c (β = 0.04). When significant, the correlations of PFNA and PFDA were negative. Of the four PFAS, only PFOA and PFOS showed a positive association, even in serum levels not as high as the values from the literature.

Suggested Citation

  • Geraldo A. Maranhao Neto & Anna Bartoskova Polcrova & Anna Pospisilova & Ludek Blaha & Jana Klanova & Martin Bobak & Juan P. Gonzalez-Rivas, 2022. "Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study," IJERPH, MDPI, vol. 19(21), pages 1-10, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:13898-:d:953391
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    References listed on IDEAS

    as
    1. Maryam Zare Jeddi & Teresa Dalla Zuanna & Giulia Barbieri & Aline S. C. Fabricio & Francesca Daprà & Tony Fletcher & Francesca Russo & Gisella Pitter & Cristina Canova, 2021. "Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy," IJERPH, MDPI, vol. 18(3), pages 1-18, January.
    2. Tahir Bashir & Emmanuel Obeng-Gyasi, 2022. "The Association between Multiple Per- and Polyfluoroalkyl Substances’ Serum Levels and Allostatic Load," IJERPH, MDPI, vol. 19(9), pages 1-12, April.
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