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The Presence of Hyperhomocysteinemia Does Not Aggravate the Cardiometabolic Risk Imposed by Hyperuricemia in Young Individuals: A Retrospective Analysis of a Cross-Sectional Study

Author

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  • Katarína Šebeková

    (Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia)

  • Radana Gurecká

    (Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia
    Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia)

  • Gabriela Repiská

    (Institute of Physiology, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia)

  • Ivana Koborová

    (Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia)

  • Ľudmila Podracká

    (Departemnt of Pediatrics of the Faculty of Medicine, Comenius University and The National Institute of Children’s Health, 833 40 Bratislava, Slovakia)

Abstract

Background: Little research has been conducted into the effects of the combined manifestation of hyperuricemia and hyperhomocysteinemia on cardiometabolic risk factors and markers in young subjects. Methods: 1298 males and 1402 females, 14-to-20-year-olds, were classified into four groups: 1/normouricemic/normohomocysteinemic, 2/normouricemic/hyperhormohomocysteinemic, 3/hyperuricemic/normohomocysteinemic, and 4/hyperuricemic/hyperhomocysteinemic. Anthropometric measures, blood pressure, plasma glucose, insulin, lipids, markers of renal function, C-reactive protein, asymmetric dimethylarginine, and blood counts were determined. Results: Hyperuricemic males (but not females) had higher odds for hyperhomocysteinemia than normouricemic ones (OR: 1.8; 95% CI: 1.4–2.3; p < 0.001). Homocysteine and uric acid levels correlated directly (males: r = 0.076, females: r = 0.120; p < 0.01, both). Two-factor analysis of variance did not reveal a significant impact of hyperhomocysteinemia on any of the investigated cardiometabolic variables in females; in males, hyperuricemia and hyperhomocysteinemia showed a synergic effect on asymmetric dimethylarginine levels. Among four groups, subjects concurrently manifesting hyperuricemia and hyperhomocysteinemia did not presented the highest continuous metabolic syndrome score—a proxy measure of cardiometabolic risk; neither the multivariate regression model indicated a concurrent significant effect of uric acid and homocysteine on continuous metabolic syndrome score in either sex. Conclusion: In young healthy subjects, hyperhomocysteinemia does not aggravate the negative health effects imposed by hyperuricemia.

Suggested Citation

  • Katarína Šebeková & Radana Gurecká & Gabriela Repiská & Ivana Koborová & Ľudmila Podracká, 2022. "The Presence of Hyperhomocysteinemia Does Not Aggravate the Cardiometabolic Risk Imposed by Hyperuricemia in Young Individuals: A Retrospective Analysis of a Cross-Sectional Study," IJERPH, MDPI, vol. 19(20), pages 1-12, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:20:p:13521-:d:946721
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    References listed on IDEAS

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    1. Ivan Soldatovic & Rade Vukovic & Djordje Culafic & Milan Gajic & Vesna Dimitrijevic-Sreckovic, 2016. "siMS Score: Simple Method for Quantifying Metabolic Syndrome," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-10, January.
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