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Relationship between Exercise Intensity and IL-6 Increase during an 80 km Long-Distance Running Race

Author

Listed:
  • Romain Jouffroy

    (Intensive Care Unit, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), 92100 Boulogne-Billancourt, France
    IRMES—Institute for Research in Medicine and Epidemiology of Sport, INSEP, 75012 Paris, France
    INSERM U-1018, Centre de Recherche en Epidémiologie et Santé des Populations, Paris Saclay University, 94800 Paris, France
    URP 7329, Université de Paris, 75012 Paris, France)

  • Dany Anglicheau

    (Necker-Enfants Malades Institute, French National Institute of Health and Medical Research U1151, 75015 Paris, France
    Paris Descartes, Sorbonne Paris Cité University, 75006 Paris, France
    Department of Nephrology and Kidney Transplantation, Necker Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), 75015 Paris, France)

  • Nicolas Mansencal

    (INSERM U-1018, Centre de Recherche en Epidémiologie et Santé des Populations, Paris Saclay University, 94800 Paris, France
    Department of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Référence des Cardiomyopathies et des Troubles du Rythme Cardiaque Héréditaires Ou Rares, Université de Versailles-Saint Quentin (UVSQ), 92100 Boulogne, France)

  • Jean François Toussaint

    (IRMES—Institute for Research in Medicine and Epidemiology of Sport, INSEP, 75012 Paris, France
    URP 7329, Université de Paris, 75012 Paris, France
    Centre d’Investigations en Médecine du Sport, Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris (AP-HP), 75004 Paris, France)

  • Juliana Antero

    (IRMES—Institute for Research in Medicine and Epidemiology of Sport, INSEP, 75012 Paris, France)

Abstract

Background : IL-6 plasma concentration (IL-6PC) reflects the systemic inflammation related to exercise intensity level. This study aims to describe the IL-6PC kinetics during a long-distance running race. IL-6PC was measured in 20 male runners before (0 km), at each refreshment point (at 21 and 53 km, i.e., k 21 and k 53 , respectively) and at the end of an 80 km long-distance run (k 80 ). Methods : IL-6PC variations (absolute and relative values in each of the three sections (S)) were calculated over S1 (0_k 21 ), S2 (k 21 _k 53 ) and S3 (k 53 _k 80 ) and compared with the exercise intensity (duration*race speed) within each section. Results : The mean IL-6PC increased during the run: 2.1 ± 0.6 ng.L −1 at 0 km, 21.0 ± 11.3 ng.L −1 at k 21 , 38.9 ± 13.0 ng.L −1 at k 53 and 49.8 ± 11.9 ng.L −1 at k 80 . Exercise intensity increased between S1 (24.2 ± 0.5) and S2 (51.9 ± 3.2) ( p = 0.04) but not between S2 and S3 (67.4 ± 4.5) ( p = 0.69). IL-6PC variation was associated with exercise intensity within S1 ( p = 0.03) and S2 ( p = 2 × 10 −3 ) and showed at least a trend within S3 ( p = 0.06). Conclusions : IL-6PC increases that occur during the early stages of a long-distance run are associated with the running intensity, and then IL-6PC remain stable after the reduction in intensity related to the decrease in running speed.

Suggested Citation

  • Romain Jouffroy & Dany Anglicheau & Nicolas Mansencal & Jean François Toussaint & Juliana Antero, 2022. "Relationship between Exercise Intensity and IL-6 Increase during an 80 km Long-Distance Running Race," IJERPH, MDPI, vol. 19(11), pages 1-7, May.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6368-:d:822630
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    References listed on IDEAS

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    1. Juliana Antero-Jacquemin & François Deni Desgorces & Frédéric Dor & Adrien Sedeaud & Amal Haïda & Philippe LeVan & Jean-François Toussaint, 2014. "Row for Your Life: A Century of Mortality Follow-Up of French Olympic Rowers," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-5, November.
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