IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i23p12433-d688359.html
   My bibliography  Save this article

Impact of Vitamin B12 Insufficiency on Sarcopenia in Community-Dwelling Older Korean Adults

Author

Listed:
  • Seon A Chae

    (Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea)

  • Hee-Sang Kim

    (Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea)

  • Jong Ha Lee

    (Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea)

  • Dong Hwan Yun

    (Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea)

  • Jinmann Chon

    (Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea)

  • Myung Chul Yoo

    (Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea)

  • Yeocheon Yun

    (Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea)

  • Seung Don Yoo

    (Department of Physical Medicine and Rehabilitation, Kyung Hee University Hospital at Gangdong, Seoul 05278, Korea)

  • Dong Hwan Kim

    (Department of Physical Medicine and Rehabilitation, Kyung Hee University Hospital at Gangdong, Seoul 05278, Korea)

  • Seung Ah Lee

    (Department of Physical Medicine and Rehabilitation, Kyung Hee University Hospital at Gangdong, Seoul 05278, Korea)

  • Sung Joon Chung

    (Department of Physical Medicine and Rehabilitation, Kyung Hee University Hospital at Gangdong, Seoul 05278, Korea)

  • Yunsoo Soh

    (Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea)

  • Chang Won Won

    (Department of Family Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea)

Abstract

Vitamin B12 (B12) is involved as a cofactor in the synthesis of myelin. A lack of B12 impairs peripheral nerve production, which can contribute to sarcopenia. In this cross-sectional study, we aimed to investigate the relationship between B12 insufficiency and sarcopenia in community-dwelling older Korean adults. A total of 2325 (1112 men; 1213 women) adults aged 70–84 years were recruited. The tools used for sarcopenia were based on the Asian Working Group for Sarcopenia (AWGS) guidelines. Individuals with low appendicular skeletal muscle mass index (ASMI) (<7.0 kg/m 2 for men; <5.4 kg/m 2 for women) and low hand grip strength (HGS) (<28 kg for men; <18 kg for women) were defined as the sarcopenia group. Among this group, those who showed low physical performance (≤9 points on the Short Physical Performance Battery (SPPB)) were defined as the severe sarcopenia group. B12 concentrations were classified into insufficient (<350 pg/mL) and sufficient (≥350 pg/mL). Univariate and multivariate logistic regression analyses were used to evaluate the relationship between sarcopenia and B12 levels. Low ASMI showed a high incidence in the B12-insufficient group. However, HGS, SPPB, and the severity of sarcopenia showed no correlation with B12. Further, insufficient B12 may affect muscle quantity rather than muscle strength or physical performance.

Suggested Citation

  • Seon A Chae & Hee-Sang Kim & Jong Ha Lee & Dong Hwan Yun & Jinmann Chon & Myung Chul Yoo & Yeocheon Yun & Seung Don Yoo & Dong Hwan Kim & Seung Ah Lee & Sung Joon Chung & Yunsoo Soh & Chang Won Won, 2021. "Impact of Vitamin B12 Insufficiency on Sarcopenia in Community-Dwelling Older Korean Adults," IJERPH, MDPI, vol. 18(23), pages 1-9, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:23:p:12433-:d:688359
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/23/12433/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/23/12433/
    Download Restriction: no
    ---><---

    More about this item

    Keywords

    vitamin B12; sarcopenia; aging; walking speed; hand grip strength;
    All these keywords.

    JEL classification:

    • B12 - Schools of Economic Thought and Methodology - - History of Economic Thought through 1925 - - - Classical (includes Adam Smith)

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:23:p:12433-:d:688359. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.