IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i16p8319-d609378.html
   My bibliography  Save this article

A Retrospective Cohort Study of Oral Leukoplakia in Female Patients—Analysis of Risk Factors Related to Treatment Outcomes

Author

Listed:
  • Shih-Wei Yang

    (Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung 204, Taiwan
    College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Department of Otolaryngology-Head and Neck Surgery, New Taipei Municipal Tucheng Hospital, New Taipei City 236, Taiwan)

  • Yun-Shien Lee

    (Department of Biotechnology, Ming Chuan University, Taoyuan 333, Taiwan
    Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan)

  • Pei-Wen Wu

    (Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung 204, Taiwan
    College of Medicine, Chang Gung University, Taoyuan 333, Taiwan)

  • Liang-Che Chang

    (College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Department of Pathology, Chang Gung Memorial Hospital, Keelung 204, Taiwan)

  • Cheng-Cheng Hwang

    (College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Department of Pathology, Chang Gung Memorial Hospital, Keelung 204, Taiwan)

Abstract

Background: The aim of this study was to make a comparison of clinicopathological characteristics of oral leukoplakia between male and female patients following carbon dioxide laser excision for oral leukoplakia and analyze the factors associated with the treatment outcomes in female patients. Methods: Medical records of patients with oral leukoplakia receiving laser surgery from 2002 to 2020 were retrospectively reviewed and analyzed statistically. Results: A total of 485 patients were enrolled, including 412 male (84.95%) and 73 female (15.05%). Regarding the locations, the predilection site of oral leukoplakia in male patients was buccal mucosa ( p = 0.0001) and that for women patients was tongue ( p = 0.033). The differences of recurrence and malignant transformation between both sexes were not significant ( p > 0.05). Among female patients, area of oral leukoplakia was the risk factor related to recurrence ( p < 0.05). Clinical morphology and postoperative recurrence were the risk factors related to malignant transformation ( p < 0.05). Conclusions: In comparison with male patients, there was no significant difference of the postoperative recurrence and malignant transformation of oral leukoplakia in female patients. Among the female patients, clinicians should pay more attention to large-sized and non-homogeneous leukoplakia, and postoperative recurrent lesions.

Suggested Citation

  • Shih-Wei Yang & Yun-Shien Lee & Pei-Wen Wu & Liang-Che Chang & Cheng-Cheng Hwang, 2021. "A Retrospective Cohort Study of Oral Leukoplakia in Female Patients—Analysis of Risk Factors Related to Treatment Outcomes," IJERPH, MDPI, vol. 18(16), pages 1-17, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8319-:d:609378
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/16/8319/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/16/8319/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Aida Kusiak & Adrian Maj & Dominika Cichońska & Barbara Kochańska & Aleksandra Cydejko & Dariusz Świetlik, 2020. "The Analysis of the Frequency of Leukoplakia in Reference of Tobacco Smoking among Northern Polish Population," IJERPH, MDPI, vol. 17(18), pages 1-9, September.
    2. Silvio Abati & Chiara Bramati & Stefano Bondi & Alessandra Lissoni & Matteo Trimarchi, 2020. "Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis," IJERPH, MDPI, vol. 17(24), pages 1-14, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Anca Maria Pop & Raluca Coroș & Alexandra Mihaela Stoica & Monica Monea, 2021. "Early Diagnosis of Oral Mucosal Alterations in Smokers and E-Cigarette Users Based on Micronuclei Count: A Cross-Sectional Study among Dental Students," IJERPH, MDPI, vol. 18(24), pages 1-10, December.
    2. Oscar Toralla & Pia Lopez Jornet & Eduardo Pons-Fuster, 2022. "The Effect of an Informative Video upon Anxiety and Stress in Patients Requiring an Oral Biopsy: A Randomized Controlled Study," IJERPH, MDPI, vol. 19(2), pages 1-11, January.
    3. Yuki Taguchi & Shigeaki Toratani & Kensaku Matsui & Seiya Hayashi & Natsuki Eboshida & Atsuko Hamada & Nanako Ito & Fumitaka Obayashi & Naohiro Kimura & Souichi Yanamoto, 2022. "Evaluation of Oral Mucosal Lesions Using the IllumiScan ® Fluorescence Visualisation Device: Distinguishing Squamous Cell Carcinoma," IJERPH, MDPI, vol. 19(16), pages 1-10, August.
    4. Nico Roeschmann & Andrea Rau & Marco R. Kesting & Eva Maier & Mayte Buchbender, 2022. "A Prospective Comparative Analysis Regarding the Assessment of Oral Mucosal Disease Using a Validated Questionnaire to Improve the Teaching of Dental Students," IJERPH, MDPI, vol. 19(15), pages 1-12, August.
    5. Xiner Wang & Guo Bai & Jizhi Liang & Qianyang Xie & Zhaohan Chen & Erda Zhou & Meng Li & Xiaoling Wei & Liuyang Sun & Zhiyuan Zhang & Chi Yang & Tiger H. Tao & Zhitao Zhou, 2024. "Gustatory interface for operative assessment and taste decoding in patients with tongue cancer," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    6. Iole Vozza, 2021. "Oral Prevention and Management of Oral Healthcare," IJERPH, MDPI, vol. 18(4), pages 1-3, February.
    7. repec:eur:ejnmjr:72 is not listed on IDEAS

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8319-:d:609378. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.